Rabies Antibody Titres in Vaccinated Reindeer

Sihvonen, Liisa; Kulonen, Katariina; Soveri, Timo; Nieminen, Markku S.

doi:10.1186/bf03548210

Cited by 9 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Double administration kept the protective level of antibodies for 24 months. These results are in line with the earlier data of Sihvonen et al (1993) demonstrated induction of good but short-duration immunity in reindeer vaccinated by one dose of inactivated adjuvanted rabies vaccine. According to their data, antibody titres were not found 1 year *According to international standards, an animal is protected from rabies if the rabies antibody level in its blood equals or exceeds 0.5 IU/ml.…”

Section: Figuresupporting

confidence: 92%

“…A number of rabies vaccines are available in Russia for use in many animal species, but there is poor data on protective immunity of deer vaccinated in the field, although there are a few reports on the duration of immunity in deer ( Sihvonen et al, 1993 ). Vaccines based on the Schelkovo-51 rabies strain have been successfully used for many years in Russia for the vaccination of pets and bovine animals.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against reindeer rabies

et al. 2022

View full text Add to dashboard Cite

The core element of the reindeer rabies eradication strategy is regular application of vaccines to obtain and uphold a vaccination coverage sufficient for the ceasing of rabies virus transmission. This article presents the results of reindeer humoral immunity intensity and duration study after the immunization with two form of inactivated rabies vaccines (adjuvanted liquid vaccine and non-adjuvanted lyophilized vaccine) based on the Shchelkovo-51 rabies virus strain. Efficiency of post-vaccine immunity was assessed by measuring the animal blood serum virus-neutralizing antibody level in a neutralization test. The study determined the efficient rabies vaccine injection dose as equal to 3 ml. A single dose of 3 ml of these vaccines induced stable production of specific neutralizing antibodies in reindeer as early as 7 day after administration, and by 30 days after immunization, it significantly exceeded the minimal threshold level accepted by OIE. Two doses of vaccines administration with an interval of 30 days are required to achieve a strong immunity with the rabies-specific virus-neutralizing antibody titer of more than 0.5 IU/ml for at least 2 years. Our data do not support the benefit of an adjuvanted vaccine for the prevention of rabies in reindeer.

show abstract

Section: Figuresupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%