Rabies control in the Republic of the Philippines: benefits and costs of elimination

Fishbein, Daniel B.; Miranda, Noel J.; Merrill, Peter; Camba, R; Meltzer, Martin I.; Carlos, E. T.; Bautista, Consolacion F.; Sopungco, P.V.; Mangahas, Lydia C.; Hernandez, Leda; Leoncio, Marylin M.; Mercado, Dolores; Gregorio, S B; Salva, Eumelia P.; Dobbins, James G.; Winkler, William G.

doi:10.1016/0264-410x(91)90246-3

Cited by 36 publications

(26 citation statements)

References 12 publications

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“…The cost of CP vaccination in agro-pastoral communities (US$1.73 per dog) compares well with studies from elsewhere, which vary between US$1.19 and 4.27 in the Philippines [31], ~US$1.3 in Tunisia and Thailand [32] and US$1.8 (US$2.6 including private costs) in Chad [29] (Table 4). The costs of the most effective and economical strategies in pastoralist communities are considerably higher (exceeding US$6 and US$4 per dog with combined CP-HH, and CP-CAHW strategies, respectively).…”

Section: Discussionsupporting

confidence: 71%

Rabies control in rural Africa: Evaluating strategies for effective domestic dog vaccination

Kaare

Lembo

Hampson

et al. 2009

Vaccine

177

178

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Effective vaccination campaigns need to reach a sufficient percentage of the population to eliminate disease and prevent future outbreaks, which for rabies is predicted to be 70%, at a cost that is economically and logistically sustainable. Domestic dog rabies has been increasing across most of sub-Saharan Africa indicating that dog vaccination programmes to date have been inadequate. We compare the effectiveness of a variety of dog vaccination strategies in terms of their cost and coverage in different community settings in rural Tanzania. Central-point (CP) vaccination was extremely effective in agro-pastoralist communities achieving a high coverage (>80%) at a low cost (US$5/dog) and inadequate (<20% coverage); combined approaches using CP and either house-to-house vaccination or trained community-based animal health workers were most effective with coverage exceeding 70%, although costs were still high (>US$6 and >US$4/dog, respectively). No single vaccination strategy is likely to be effective in all populations and therefore alternative approaches must be deployed under different settings. CP vaccination is cost-effective and efficient for the majority of dog populations in rural Tanzania and potentially elsewhere in sub-Saharan Africa, whereas a combination strategy is necessary in remote pastoralist communities. These results suggest that rabies control is logistically feasible across most of the developing world and that the annual costs of effective vaccination campaigns in Tanzania are likely to be affordable.

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Section: Discussionsupporting

confidence: 71%

Rabies control in rural Africa: Evaluating strategies for effective domestic dog vaccination

Kaare

Lembo

Hampson

et al. 2009

Vaccine

177

178

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“…Thirteen of the included studies described rabies, and all investigated vaccination as an option of controlling rabies in either dogs or wildlife. Most of these studies showed that those control programs that include vaccination are often cost-effective over a long time span, ranging from 4.1 to 11.0 years in the Philippines (Fishbein et al 1991), 5.9 years in N’Djaména (Zinsstag et al 2009), and 6 years in Bhutan (Tenzin and Ward 2012). …”

Section: Discussionmentioning

confidence: 99%

Quantitative Outcomes of a One Health approach to Study Global Health Challenges

et al. 2018

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Having gained momentum in the last decade, the One Health initiative promotes a holistic approach to address complex global health issues. Before recommending its adoption to stakeholders, however, it is paramount to first compile quantitative evidence of the benefit of such an approach. The aim of this scoping review was to identify and summarize primary research that describes monetary and non-monetary outcomes following adoption of a One Health approach. An extensive literature search yielded a total of 42,167 references, of which 85 were included in the final analysis. The top two biotic health issues addressed in these studies were rabies and malaria; the top abiotic health issue was air pollution. Most studies described collaborations between human and animal (n = 42), or human and environmental disciplines (n = 41); commonly reported interventions included vector control and animal vaccination. Monetary outcomes were commonly expressed as cost–benefit or cost–utility ratios; non-monetary outcomes were described using disease frequency or disease burden measurements. The majority of the studies reported positive or partially positive outcomes. This paper illustrates the variety of health challenges that can be addressed using a One Health approach, and provides tangible quantitative measures that can be used to evaluate future implementations of the One Health approach. Electronic supplementary materialThe online version of this article (10.1007/s10393-017-1310-5) contains supplementary material, which is available to authorized users.

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“…Because of this many people fail to seek, cannot afford or forego treatment altogether. The vast majority of human rabies cases in the country never received any form of anti-rabies treatment [Fishbein et al, 1991].…”

Section: Introductionmentioning

confidence: 99%

Case report: Rapid ante‐mortem diagnosis of a human case of rabies imported into the UK from the Philippines

Smith¹,

McElhinney²,

Parsons³

et al. 2002

Journal of Medical Virology

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The United Kingdom is free from rabies, with the last human death from indigenous rabies recorded in 1902. However, between 1946 and 2000, 20 deaths were reported in the United Kingdom in people who were bitten and infected while abroad in rabies endemic areas. The rapid diagnosis of suspected human rabies cases influences the use of anti-rabies post-exposure prophylaxis for potential contacts with the victim. In addition, the occurrence of a human rabies case requires urgent investigation to support patient management policies. In May 2001, a case of human rabies imported into the United Kingdom from the Philippines was identified. A 55-year-old man was admitted to University College Hospital, London, with clinical symptoms and a history consistent with exposure to rabies. Saliva, cerebrospinal fluid), and skin biopsies (from the wound site and nape of the neck) were submitted for conventional ante-mortem diagnostic techniques. Established diagnostic techniques, including the fluorescent antibody test (FAT), mouse inoculation test, (MIT) and the rabies tissue culture inoculation test (RTCIT), failed to detect the virus. In contrast, hemi-nested reverse transcription-polymerase chain reaction (RT-PCR), followed by automated sequencing confirmed the presence of classical rabies virus (genotype 1) in both the saliva and skin specimens within 36 hr of sample submission. Subsequent phylogenetic analysis demonstrated that this isolate was closely related to that of canine variants currently circulating in the Philippines.

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Rabies control in the Republic of the Philippines: benefits and costs of elimination

Cited by 36 publications

References 12 publications

Rabies control in rural Africa: Evaluating strategies for effective domestic dog vaccination

Rabies control in rural Africa: Evaluating strategies for effective domestic dog vaccination

Quantitative Outcomes of a One Health approach to Study Global Health Challenges

Case report: Rapid ante‐mortem diagnosis of a human case of rabies imported into the UK from the Philippines

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