Rabies vaccination and multiple sclerosis relapse: A retrospective cohort study

Abstract

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ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs

“…Fifteen studies met the eligibility criteria, 1 of them investigated the risk of MS exacerbation following any vaccination, 17 and 14 studies addressed safety concerns related to individual vaccines (hepatitis B, tetanus, influenza, BCG, varicella, tick-borne encephalitis (TBE), rabies, and yellow fever). [18][19][20][21][22][23][24][25][26][27][28][29][30][31] Evidence on the safety of TBE, rabies, and yellow fever vaccination will be reviewed in Question 7. Details on the methodology, level of the evidence and results of the included studies are available in Supplemental Appendix 3.…”

“…6 Six studies have evaluated the efficacy and/or safety of travel vaccines in pwMS. [26][27][28][29][30][31] Details on the methodology, level of the evidence, and results of these studies are available in Supplemental Appendix 3.…”

European Committee for Treatment and Research in Multiple Sclerosis and European Academy of Neurology consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs

“…Rabies . A single self‐controlled retrospective study ( Level 3 ) reported the risk of relapses in 55 patients with MS who underwent pre‐exposure rabies vaccination [26]. The annualized relapse rate in the pre‐exposure, exposure risk and post‐risk periods were 0.44, 0.22, and 0.10, respectively (rate ratio for exposure‐risk to pre‐exposure periods, 0.51 [95% CI 0.10–1.68]).…”

“…Fifteen studies met the eligibility criteria, one of which investigated the risk of MS exacerbation following any vaccination [17], and 14 of which addressed safety concerns related to individual vaccines (hepatitis B, tetanus, influenza, BCG, varicella, tick-borne encephalitis [TBE], rabies, and yellow fever) [18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Evidence on the safety of TBE, rabies, and yellow fever vaccination will be reviewed in Question 7.…”

“…Six studies have evaluated the efficacy and/or safety of travel vaccines in pwMS [26][27][28][29][30][31]. Details on the methodology, level of the evidence and results of these studies are available in Appendix 3.…”