Rabies virus receptors

Pathogenesis

“…When the amino acid sequence of the rabies virus glycoprotein was compared with that of snake venom neurotoxins, a significant sequence similarity was found between a segment (residues 151-238) of the rabies virus glycoprotein and the entire long neurotoxin sequence (71-74 residues) (Lentz, Wilson, Hawrot, & Speicher, 1984). This suggests that this region of the rabies virus glycoprotein is likely a recognition site for the acetylcholine receptor (Lentz, 1985). This suggests that this region of the rabies virus glycoprotein is likely a recognition site for the acetylcholine receptor (Lentz, 1985).…”

Domains of Virus Glycoproteins

“…These findings raise the possibility that the neuronal cell tropism and resulting pathogenesis of rabies virus may be due to the affinity of the viral glycoprotein for the acetylcholine receptor. Lentz (1985) pointed out, however, that the acetylcholine receptor is not the only receptor for rabies virus since cells lacking this receptor are susceptible to the virus. The similarity between a domain of the rabies glycoprotein and that of neurotoxins may reflect an evolutionary relatedness between this viral protein and a cellular protein.…”

Identification of bovine viral diarrhea virus receptor in different cell types

“…Some of the receptor molecules function as viral receptors for several viruses. Two neural cell-specific molecules, the acetylcholine and /3-adrenergic receptors, have been identified as attachment proteins for rabies virus and reovirus type 3 (Co et al, 1985;Kucera et al, 1985;Lentz, 1985). Some molecules, like mannosedphosphate and heparin sulfate, which are used for initial binding by varicella-zoster and herpes simplex viruses (Gabel et al, 1989;Wudunn and Spear, 1989)) are present on many types of cells.…”