Rabies virus transmission via solid organs or tissue allotransplantation

Lu, Xin; Zhu, Wuyang; Wu, Guizhen

doi:10.1186/s40249-018-0467-7

Cited by 33 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Operationally, exposure is defined as transdermal or mucosal contamination with saliva, brain tissue, or other virus-containing substances 2 . Human cases continue to be documented following exposure via these well-recognized routes 38 – 40 . Incubation periods range from less than a week to greater than a year (i.e.…”

Section: Pathogenesismentioning

confidence: 99%

Update on lyssaviruses and rabies: will past progress play as prologue in the near term towards future elimination?

Rohde

Rupprecht²

2020

Fac Rev

View full text Add to dashboard Cite

Rabies is an ancient, much-feared, and neglected infectious disease. Caused by pathogens in the family Rhabdoviridae, genus Lyssavirus, and distributed globally, this viral zoonosis results in tens of thousands of human fatalities and millions of exposures annually. All mammals are believed susceptible, but only certain taxa act as reservoirs. Dependence upon direct routing to, replication within, and passage from the central nervous system serves as a basic viral strategy for perpetuation. By a combination of stealth and subversion, lyssaviruses are quintessential neurotropic agents and cause an acute, progressive encephalitis. No treatment exists, so prevention is the key. Although not a disease considered for eradication, something of a modern rebirth has been occurring within the field as of late with regard to detection, prevention, and management as well as applied research. For example, within the past decade, new lyssaviruses have been characterized; sensitive and specific diagnostics have been optimized; pure, potent, safe, and efficacious human biologics have improved human prophylaxis; regional efforts have controlled canine rabies by mass immunization; wildlife rabies has been controlled by oral rabies vaccination over large geographic areas in Europe and North America; and debate has resumed over the controversial topic of therapy. Based upon such progress to date, there are certain expectations for the next 10 years. These include pathogen discovery, to uncover additional lyssaviruses in the Old World; laboratory-based surveillance enhancement by simplified, rapid testing; anti-viral drug appearance, based upon an improved appreciation of viral pathobiology and host response; and improvements to canine rabies elimination regionally throughout Africa, Asia, and the Americas by application of the best technical, organizational, economic, and socio-political practices. Significantly, anticipated Gavi support will enable improved access of human rabies vaccines in lesser developed countries at a national level, with integrated bite management, dose-sparing regimens, and a 1 week vaccination schedule.

show abstract

Section: Pathogenesismentioning

confidence: 99%

Update on lyssaviruses and rabies: will past progress play as prologue in the near term towards future elimination?

Rohde

Rupprecht²

2020

Fac Rev

View full text Add to dashboard Cite

show abstract

“…Dog slaughtering and the process of handling, catching, loading, transportation, holding and keeping in the cages increases the risk of transmission to the butchers (Broban et al 2018). Non-bite exposure methods are inhalation, organ transplants and contamination of abrasions, open wounds, mucous membranes with rabies virus laden saliva or with infectious material such as brain tissue from a rabid animal (Lu et al 2018;Pantha et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Surveillance of Animal Rabies in Burkina Faso: A Retrospective Laboratory Data from 2008 to 2012

2021

Int J Vet Sci

View full text Add to dashboard Cite

Rabies causes more than 59,000 deaths each year worldwide with 95% of cases in Africa and Asia. It is endemic in most of African countries and 99% of human rabies cases are dog mediated. This study aimed to review data on animal rabies surveillance and factors associated with dogs’ rabies in Burkina Faso from 2008 to 2012. Data on submitted samples for analysis using Fluorescent Anti-body Test and confirmed cases in animals were obtained from the National Livestock Laboratory. These data were associated with the geographical regions where the samples originated, species and years. For dogs, data on age, sex, dogs’ ownership and vaccination status have also been collected. From 2008 to 2012, 1352 animal samples were analyzed for rabies confirmation with an average of 315 samples by year. Canine rabies was most suspected with 90% of positive samples. On overall, 77.3% of samples were positive and the highest positive percentage was found during 2012 (89.8%). Rabies was confirmed in donkeys (100%), dogs (78.2%), cats (77.3%), monkeys (53.8%), shrews (50%), and rodents (35.3%). Regarding dog’s rabies, positive samples were also found among vaccinated dogs and the highest positive percentage (91%) was in 2012.These findings demonstrate that rabies is widely distributed in animal species in Burkina Faso and dogs’ vaccination against rabies must be followed seriously as possible vaccine fail occurs after vaccination.

show abstract

“…Other infection routes are extremely rare, with inhalation of aerosol generated from infected specimens (e.g. during autopsy), contamination of a wound, entrance from a mucous membrane, or through solid organ or corneal transplantation, reported only in few cases [28][29][30][31]. RABV infection of polar foxes from ingestion of infected carcasses has been described [32].…”

Section: Epidemiologymentioning

confidence: 99%

Rabies in Europe: An epidemiological and clinical update

Riccardi

Giacomelli

Antonello

et al. 2021

European Journal of Internal Medicine

View full text Add to dashboard Cite

Rabies is a vaccine preventable zoonotic disease with a significant mortality burden worldwide. Several years of vaccination campaigns in wildlife animals have now achieved the control of rabies in Western Europe through a vaccination belt in front of endemic Eastern European countries. Nevertheless, rabies could be imported both by travellers from areas without an active public control of the disease or by animals coming from areas where the virus circulates in wildlife fauna. The knowledge of the current world epidemiology combined with a high index of clinical suspicion are needed to reach a diagnosis of rabies, especially in case of atypical presentation or without a history of animal exposure. The pre-travel counselling to people visiting highly endemic areas is essential to give information on how to reduce exposure to potential sources of infection and to select those subjects who could benefit from pre-travel vaccination. Rabies is almost invariably fatal, but the prompt administration of a vaccine course combined with anti-rabies immunoglobulins significantly reduces the probability to develop life-threatening consequences. In this review, we give a brief epidemiological and clinical update about rabies in Europe.

show abstract

Rabies virus transmission via solid organs or tissue allotransplantation

Cited by 33 publications

References 40 publications

Update on lyssaviruses and rabies: will past progress play as prologue in the near term towards future elimination?

Update on lyssaviruses and rabies: will past progress play as prologue in the near term towards future elimination?

Surveillance of Animal Rabies in Burkina Faso: A Retrospective Laboratory Data from 2008 to 2012

Rabies in Europe: An epidemiological and clinical update

Contact Info

Product

Resources

About