2014
DOI: 10.4161/cc.29279
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Rac1-dependent recruitment of PAK2 to G2phase centrosomes and their roles in the regulation of mitotic entry

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Cited by 32 publications
(37 citation statements)
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“…Treatment of proliferating cells with either LCGT further results in inhibited cell cycle progression at the G1-S, as well as the G2-M boundaries [62,64,91,92]. Rac1 glucosylation suppresses cyclin D expression and delays cyclin B activation, resulting in G1-S arrest and delayed G2-M transition, respectively (Figure 16.6) [64,93,94].…”
Section: Glycosyltransferase-dependent Effectsmentioning
confidence: 95%
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“…Treatment of proliferating cells with either LCGT further results in inhibited cell cycle progression at the G1-S, as well as the G2-M boundaries [62,64,91,92]. Rac1 glucosylation suppresses cyclin D expression and delays cyclin B activation, resulting in G1-S arrest and delayed G2-M transition, respectively (Figure 16.6) [64,93,94].…”
Section: Glycosyltransferase-dependent Effectsmentioning
confidence: 95%
“…Rac1 glucosylation suppresses cyclin D expression and delays cyclin B activation, resulting in G1-S arrest and delayed G2-M transition, respectively (Figure 16.6) [64,93,94]. In cells treated with RhoA-glucosylating LCGTs such as TcdA and TcdB, RhoAdependent contractile ring formation in cytokinesis is blocked.…”
Section: Glycosyltransferase-dependent Effectsmentioning
confidence: 96%
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“…Treatment of synchronized HeLa cells in G 2 phase of the cell cycle with this specific Rac-inhibiting toxin prevented the activation of PAK, Aurora A, and Cdk1/cyclinB at the G 2 /M border and delayed entry of cells into mitosis for 2 h. This observation indicates Rac—but not Cdc42 or Rho—as the missing player in this process 7 . Where is Rac’s mitotic point of entry?…”
mentioning
confidence: 95%
“…Published in this volume of Cell Cycle , May and coworkers tackled this question by extending the work by Ando et al In cleverly designed experiments they used a variant of Clostridium difficile toxin B that selectively inhibits Rac activity in living cells 7 . Treatment of synchronized HeLa cells in G 2 phase of the cell cycle with this specific Rac-inhibiting toxin prevented the activation of PAK, Aurora A, and Cdk1/cyclinB at the G 2 /M border and delayed entry of cells into mitosis for 2 h. This observation indicates Rac—but not Cdc42 or Rho—as the missing player in this process 7 .…”
mentioning
confidence: 99%