2008
DOI: 10.1200/jco.2008.26.15_suppl.20503
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Race and albuterol premedication are risk factors for hypersensitivity reactions to cetuximab

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Cited by 7 publications
(10 citation statements)
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“…A study conducted in the USA reported an association between Caucasians and the occurrence of hypersensitivity reactions. 5 No association was found with age and sex. In another study, O’Neil et al.…”
Section: Introductionmentioning
confidence: 90%
“…A study conducted in the USA reported an association between Caucasians and the occurrence of hypersensitivity reactions. 5 No association was found with age and sex. In another study, O’Neil et al.…”
Section: Introductionmentioning
confidence: 90%
“…Irinotecan and oxaliplatin FOLFIRI, FOLFOX and IROX are less toxic to AAs than Whites 34% vs 48%, P = 0.004, for severe toxicity [95] 5% vs 17%, P = 0.004 for diarrhea Fluoropyrimidines 5-FU regimens in the adjuvant setting differed between AA and Whites, with AA experiencing statistically significantly lower rates Diarrhea (P < 0.001) [98] Nausea (P < 0.001) Vomiting (P = 0.01) Stomatitis (P < 0.001) Overall toxicity (P = 0.005) DPD deficiency AA, particularly AA women, have significantly reduced DPD enzyme activity compared with Whites, which may predispose this population to less 5-FU toxicity - [99] Cetuximab In a retrospective analysis, it was shown race was strongly associated with HSR to cetuximab among patients with CRC and head and neck cancer, with Whites experiencing HSR more frequently than AA (Fisher exact) P = 0.017 [100] …”
Section: Toxicity Difference Referencementioning
confidence: 99%
“…An atopic history and Caucasian origin are significantly associated with this hypersensitivity, but these criteria are not sufficient to select patients at risk 4,7. In this context, identifying specific IgE against cetuximab seems to be a good candidate.…”
Section: Discussionmentioning
confidence: 99%
“…An atopic history and Caucasian origin are significantly associated with this hypersensitivity, but these criteria are not sufficient to select patients at risk. 4 , 7 In this context, identifying specific IgE against cetuximab seems to be a good candidate. According to the study by Chung et al, 8 anticetuximab IgE assays have high sensitivity (92%) and specificity (90%) if used as a diagnostic test to identify patients who are likely to develop life-threatening reactions.…”
Section: Discussionmentioning
confidence: 99%
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