Race and Gender Disparity in the Surgical Management of Hepatocellular Cancer: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Program Registry

Abstract

Background The existence of race and gender disparity has been described in numerous areas of medicine. The management of hepatocellular cancer is no different, but in no other area of medicine, is the treatment algorithm more complicated by local, regional, and national health care distribution policy. Methods Multivariate logistic regression and Cox‐regression were utilized to analyze the treatment of patients with hepatocellular cancer registered in SEER between 1999 and 2013 to determine the incidence and effects of racial and gender disparity. Odd ratios (OR) are relative to Caucasian males, SEER region, and tumor characteristics. Results The analysis of 57,449 patients identified the minority were female (25.31%) and African‐American (16.26%). All tumor interventions were protective (p < 0.001) with respect to survival. The mean survival for all registered patients was 13.01 months with conditional analysis, confirming that African‐American men were less likely to undergo ablation, resection, or transplantation (p < 0.001). Women were more likely to undergo resection (p < 0.001). African‐American women had an equivalent OR for resection but had a significantly lower transplant rate (p < 0.001). Conclusions Utilizing SEER data as a surrogate for patient navigation in the treatment of hepatocellular cancer, our study identified not only race but gender bias with African‐American women suffering the greatest. This is underscored by the lack of navigation of African‐Americans to any therapy and a significant bias to navigate female patients to resection potentially limiting subsequent access to definitive therapy namely transplantation.

Social Determinants of Health Needs and Health-Related Quality of Life Among Surgical Patients

“…In particular, surgical inequities related to socioeconomic status (SES), geographic location, and the social constructs of gender, race, ethnicity, and disability status have been well-documented. [3][4][5][6][7][8][9][10][11][12] Given the pervasive impact of SDOH, addressing the determinants is imperative to promoting health among surgical patients. SDOH can be addressed at multiple levels: systems, community, and individual.…”

“…SDOH have been extensively associated with inequities in surgical access, quality of care, and outcomes. In particular, surgical inequities related to socioeconomic status (SES), geographic location, and the social constructs of gender, race, ethnicity, and disability status have been well-documented 3–12 . Given the pervasive impact of SDOH, addressing the determinants is imperative to promoting health among surgical patients.…”