Couple therapy involves helping couples develop capacities to connect and collaborate amid the vast array of differences that typically emerge in couples' relationships over time. The literature on attending to dynamics of difference and diversity in couple therapy, such as differences across gender orientation, culture, race, and sexual orientation, has been growing. However, there has been very limited attention to religious differences and religious diversity in couple therapy. Dynamics of religion and spirituality can be so highly nuanced within personalized meanings and contexts that we could say there are religious and spiritual differences at some level within every couple, even if both persons identify with the same religious or spiritual (RS) traditions or disidentify with religion and spirituality altogether. For some couples, RS differences are enlivening sources of healthy connection and resilience in difficult times, while other couples can experience these differences as conflictual, painful, and estranging.