Lesbian, gay, bisexual, and transgender (LGBT) female physicians of color experience an interesting intersectionality of identities. While socially advantaged due to their status as physicians, they are also struck with socially disadvantageous statuses by being female, person of color, and LGBT. These individuals are united by recurring themes of oppression, lack of visibility, perceived inferiority, and of course empowerment. The purpose of this paper is to review the current literature on LGBT female physicians of color and to provide a framework for potential solutions. By increasing the number of LGBT female physicians of color in both the general workforce and positions of leadership, the patient-physician relationship can be strengthened, improving healthcare outcomes for the underserved. Further, improved physician satisfaction will promote physician wellbeing and longevity and protect against physician burnout.