Race Effects of Inhaled Nitric Oxide in Preterm Infants: An Individual Participant Data Meta-Analysis

Abstract

iNO therapy should be considered for preterm African American infants at high risk for BPD. iNO to prevent BPD in African Americans may represent an example of a racially customized therapy for infants.

Prevention of Bronchopulmonary Dysplasia: A Summary of Evidence-Based Strategies

“…(113)(114) A recent individual patient meta-analysis using data from a subset of trials suggested that inhaled nitric oxide may reduce BPD risk among black preterm infants. (115) This promising finding requires validation in future studies.…”

Re-conceptualizing Associations between Race and Morbidities of Extreme Prematurity

“…Recent reports have investigated the relationship between race and BPD and respiratory outcomes following preterm birth. 7,8,[13][14][15][16][17] Implicit in many such investigations is the question as to whether genetic sequence differences between racial groups are responsible for differences in risk of diseases such as BPD.…”

Childhood Pulmonary Function, Exercise Capacity, and Exhaled Nitric Oxide Levels: Outcomes following Neonatal Treatment with Inhaled Nitric Oxide to Prevent Bronchopulmonary Dysplasia

“…In post hoc analysis of the NO CLD study, there had been statistically significant interactions between age at study entry and ethnicity on treatment effect. 8,21 In that study, the benefit of survival without chronic lung disease was seen in the group treated at 7 to 14 days. Therefore, we performed secondary subgroup analyses to assess the effects of those variables on cardiopulmonary outcomes at school age.…”