Race/ethnicity, but not income, are associated with increased odds of shellfish allergy

Abrams, Elissa M.; Gerdts, Jennifer; Gruber, Jackie; Lemoine-Courcelles, Cathérine; Simons, Elinor; Protudjer, Jennifer L. P.

doi:10.1016/j.jaip.2020.11.003

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…An Australian study also reported a higher prevalence of nut allergy in children of mothers with higher education and socio-economic index [ 13 ]. Our finding that certain FA (i.e., peanut, fish, shellfish, and egg) occurred more frequently in those of Asian race/ethnicity has also been reported by Gupta [ 11 , 12 ] and others [ 14 , 15 ]. A small Canadian study involving 151 respondents reported a higher prevalence of shellfish allergy in Historically Underrepresented (i.e., Indigenous, Asian, Black, and East Indian) versus white participants [ 14 ].…”

Section: Discussionsupporting

confidence: 87%

“…Our finding that certain FA (i.e., peanut, fish, shellfish, and egg) occurred more frequently in those of Asian race/ethnicity has also been reported by Gupta [ 11 , 12 ] and others [ 14 , 15 ]. A small Canadian study involving 151 respondents reported a higher prevalence of shellfish allergy in Historically Underrepresented (i.e., Indigenous, Asian, Black, and East Indian) versus white participants [ 14 ]. American studies have also reported a higher frequency of overall FA in Asian children [ 12 , 15 ] and adults [ 11 ] although they have not examined South and Southeast/East Asians separately as we did.…”

Section: Discussionsupporting

confidence: 87%

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Demographic characteristics associated with food allergy in a Nationwide Canadian Study

Clarke

Elliott

Pierre

et al. 2021

Allergy Asthma Clin Immunol

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Introduction We conducted a nationwide Canadian telephone survey on food allergy prevalence between February 2016 and January 2017, targeting vulnerable populations (New, Indigenous, and lower-income Canadians). Objective To examine the independent effect of demographic characteristics on food allergy. Methods Canadian households with vulnerable populations were targeted using Canadian Census data and the household respondent reported whether each household member had a perceived (self-reported) or probable (self-report of a convincing history or physician diagnosis) food allergy. The association between perceived and probable food allergy and demographic characteristics was assessed through weighted multivariable random effects logistic regressions. Results Children, females, Canadian-born participants, adults with post-secondary education, and those residing in smaller households were more likely to report perceived or probable food allergy. Although immigrant parents self-reported less food allergy, Canadian-born children of Southeast/East Asian immigrant versus other immigrant or Canadian-born parents reported more food allergy. Conclusion We have demonstrated clear associations between demographic characteristics and food allergy, which may provide important clues to the environmental determinants of food allergy.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Demographic characteristics associated with food allergy in a Nationwide Canadian Study

Clarke

Elliott

Pierre

et al. 2021

Allergy Asthma Clin Immunol

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“…NF1 is an autosomal dominant genetic syndrome due to mutations in the NF1 tumor suppressor gene and is characterized by café au lait spots, dermal and plexiform neurofibromas, pheochromocytomas, optic gliomas, and malignant peripheral nerve sheath tumors ( 46 , 47 ). Rare instances of ACC in patients with NF1 have been reported in the literature ( 48 – 51 ). Carney complex is an autosomal dominant tumor syndrome characterized by skin pigmentary abnormalities, myxomas, endocrine tumors, and schwannomas ( 52 ).…”

Section: Geneticsmentioning

confidence: 99%

Pediatric adrenocortical carcinoma

Ilanchezhian

Varghese²,

Glod³

et al. 2022

Front. Endocrinol.

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Adrenocortical carcinoma (ACC) is a rare endocrine malignancy of the adrenal gland with an unfavorable prognosis. It is rare in the pediatric population, with an incidence of 0.2-0.3 patients per million in patients under 20 years old. It is primarily associated with Li-Fraumeni and Beckwith-Wiedemann tumor predisposition syndromes in children. The incidence of pediatric ACC is 10-15fold higher in southern Brazil due to a higher prevalence of TP53 mutation associated with Li-Fraumeni syndrome in that population. Current treatment protocols are derived from adult ACC and consist of surgery and/or chemotherapy with etoposide, doxorubicin, and cisplatin (EDP) with mitotane. Limited research has been reported on other treatment modalities for pediatric ACC, including mitotane, pembrolizumab, cabozantinib, and chimeric antigen receptor autologous cell (CAR-T) therapy.

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“…With the development of industrialisation, lifestyle modernisation and environmental pollution, allergic diseases are increasing, affecting more than 20% of the global population (Abrams et al. 2021 ). However, the detailed mechanism is not yet fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

Wang

et al. 2022

Pharmaceutical Biology

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Context Saposhnikovia divaricata (Turcz.) Schischk (Apiaceae) (SD) has various pharmacological activities, but its effects on type I allergy (TIA) have not been comprehensively studied. Objective This study evaluates the treatment and molecular mechanisms of SD against TIA. Materials and methods The effective components and action targets of SD were screened using TCMSP database, and allergy-related targets of SD were predicted using GeneCards and OMIM database. The obtained target intersections were imported into David database for GO analysis, and used R software to perform KEGG analysis. The RBL-2H3 cells sensitised by DNP-IgE/DNP-BSA were treated with different concentrations of SD (root decoction, 0.5, 1, and 2 mg/mL), prim- O -glucosylcimifugin (POG, 10, 40, and 80 μg/mL) and the positive control drug–ketotifen fumarate (KF, 30 μM) for 12 h, then subjected to cell degranulation and qPCR analysis. Results Eighteen active compounds of SD and 38 intersection targets were obtained: TIA-related signal pathways mainly include calcium signal pathway, PI3K–Akt signal pathway and MAPK signal pathway. Taking the β-Hex release rate of the model group as the base, the release rate of SD and POG in high dose groups were 43.79% and 57.01%, respectively, which were significantly lower than model group ( p < 0.01), and significantly lower than KF group (63.83%, p < 0.01, p < 0.05). SD and POG could down-regulate the expression of related proteins in the Lyn/Syk, PI3K/AKT and MAPK signalling pathways. Discussion and conclusion Saposhnikovia divaricata could inhibit IgE-induced degranulation of mast cells, providing a scientific basis for further research and clinical applications of SD in TIA treatment.

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Race/ethnicity, but not income, are associated with increased odds of shellfish allergy

Cited by 7 publications

References 7 publications

Demographic characteristics associated with food allergy in a Nationwide Canadian Study

Demographic characteristics associated with food allergy in a Nationwide Canadian Study

Pediatric adrenocortical carcinoma

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

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