Race/ethnicity determines the relationships between oxidative stress markers and blood pressure in individuals with high cardiovascular disease risk

Abstract

Oxidative stress (OS) and cardiovascular (CV) reactivity are related to CV morbidity and mortality. However, little is known about the relationships between these CV risk factors and their confounders. We hypothesize that higher OS is linked to higher blood pressure (BP) reactivity to acute laboratory stressors and in the natural setting. We studied 137 subjects with a family history of hypertension and early myocardial infarction. There were 63 European Americans (EA’s) (38 males) and 74 African Americans (AA’s) (35 males), aged 19 to 36(27.6+/−3.1). The protocol included a competitive video game, cold stressor, and ambulatory BP recording. Blood samples were drawn 6 times for OS markers (8-OHdG and 8-Isoprostane) assay. Repeated measures analyses of covariance were used to test for mean differences and Pearson correlations were used to test OS and BP associations. There were no significant race/ethnicity differences in BP reactivity to either stressor (both p’s>0.48). 8-OHdG levels were significantly lower across all time points for AA’s than for EA’s (p<0.05) while levels of 8-isoprostane did not differ significantly (p>.10). Averaged 8-OHdG levels significantly correlated with SBP reactivity (r=0.45, <0.01) and 24-hour, daytime, and nighttime SBP (r range=0.37 to 0.42, all p’s<0.02) for EA’s but not for AA’s, whereas 8-isoprostane levels were significantly correlated with reactive SBP and nighttime DBP (both r’s=0.38, p<0.01) for AA’s but not for EA’s. These findings suggest a link between OS and BP changes in subjects at high risk for CV disease. Further, race/ethnicity determines which OS marker will impact BP variation implying race/ethnicity differences in OS related mechanisms of CVD.

The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease

“…Observations from our cohort of CKD patients linked BP variability with a prevalence of sleep disorders such as obstructive sleep apnea, insomnia and restless leg syndrome further supporting the hypothesis that endothelial dysfunction and glomerular damage play a crucial role in the development of BP variation and in worsen disease progression in these patients [40][41][42]. Evidences for the correlation of oxidative stress and BP variability can be observed in population at high cardiovascular risk such as subjects with familial history of essential hypertension and myocardial infarction and type 2 diabetes mellitus and hypertension where BP variations significantly correlate with 8-hydroxydeoxyguanosine, 8-isoprostane and diacron-reactive oxygen metabolites respectively [43,44].…”

Brain Correlates of Mental Stress-Induced Myocardial Ischemia

“…This research is subject to several limitations. First, our findings are not generalizable outside of populations of CAD patients (119, 120). .…”

“…This is typical of the racial distribution of Georgia, but not many other areas of the country. Although AAs have an increase in hypertension (119) and oxidative stress (120), studies have not shown an increase in stress-induced blood pressure reactivity (120). Therefore the impact on race in this group is unclear.…”

Sardine proteins (Sardina pilchardus) combined with green lemon zest (Citrus latifolia) improve blood pressure, lipid profile and redox status in diabetic hypertensive rats

“…These two diseases affect a large segment of population in the world with 422 million for the diabetes [WHO (World Health Organization), 2016] and 9.4 million deaths worldwide every year for hypertension (Lim et al, 2012). Diabetes mellitus and hypertension were enhanced oxidative stress and changes antioxidant capacity (Yang et al, 2011;Kapuku et al, 2016). Several reports had shown that the chronic administration of ouabain to Wistar rats induces hypertension (You et al, 2014;Davel et al, 2014).…”