Race‐specific WBC and neutrophil count reference intervals

Lim, E-M; Cembrowski, George; Cembrowski, Mark S.; Clarke, Gwen

doi:10.1111/j.1751-553x.2010.01223.x

Cited by 81 publications

(67 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To explain initial longer telomere length observed in Blacks, several researchers have noted that white blood cell admixture differs by race (Lim, Cembrowski, Cembrowski, & Clarke, 2010),. Zhu and colleagues found that Black individuals have longer LTL in adolescence, and Hunt and colleagues present cross-sectional data that suggested LTL was longer in Blacks vs.…”

Section: Discussionmentioning

confidence: 99%

Race-related health disparities and biological aging: Does rate of telomere shortening differ across blacks and whites?

Rewak

Buka

Prescott

et al. 2014

Biological Psychology

View full text Add to dashboard Cite

Summary Recent work suggests that leukocyte telomere length (LTL), a marker of cellular aging, is sensitive to effects of social stress and may also provide early indication of premature aging. Using data from a birth cohort with LTL information at birth and in middle adulthood we examined a potential source of race-based health disparity by testing the hypothesis that Blacks would demonstrate a faster rate of telomere shortening than Whites. Linear regression analyses were conducted and adjusted for pack years, BMI, education and social factors, diet, exercise, marital status, and age. At birth black individuals had LTLs that were longer, on average, than their White counterparts (b = 3.85, p < 0.01). However, rate of shortening was greater for Blacks, who showed a larger difference in length between birth and adulthood (b = 5.10, p = 0.01) as compared with Whites, resulting in smaller racial differences in absolute adult LTL.

show abstract

Section: Discussionmentioning

confidence: 99%

Race-related health disparities and biological aging: Does rate of telomere shortening differ across blacks and whites?

Rewak

Buka

Prescott

et al. 2014

Biological Psychology

View full text Add to dashboard Cite

show abstract

“…One potential mechanism might be related to the low WBC count seen in blacks. 20 While low WBC counts have not conferred an increased nosocomial infection risk amongst blacks generally, it may potentially influence the susceptibility to post-stroke immunodepression. Infections were also more common in deep hemorrhages, which were more common in blacks, than in lobar hemorrhages.…”

Section: Discussionmentioning

confidence: 99%

Infection After Intracerebral Hemorrhage

Lord

Langefeld

Sekar

et al. 2014

Stroke

View full text Add to dashboard Cite

Background and Purpose Risk factors for infections after intracerebral hemorrhage (ICH) and their association with outcomes are unknown. We hypothesized there are predictors of post-stroke infection and infections drive worse outcomes. Methods We determined prevalence of infections in a multicenter, triethnic study of ICH. We performed univariate and multivariate analyses to determine the association of infection with admission characteristics and hospital complications. We performed logistic regression on association of infection with outcomes after controlling for known determinants of prognosis after ICH (volume, age, infratentorial location, intraventricular hemorrhage, Glasgow Coma Score). Results Among 800 patients, infections occurred in 245 (31%). Admission characteristics associated with infection in multivariable models were ICH volume (OR 1.02 per mL, 95% CI 1.01–1.03), lower GCS (OR 0.91 per point, 95% CI 0.87–0.95), deep location (reference lobar, OR 1.90, 95% CI 1.28–2.88), and black race (reference white, OR 1.53, 95% CI 1.01–2.32). In a logistic regression of admission and hospital factors, infections were associated with intubation (OR 3.1, 95% CI 2.1–4.5), dysphagia (with PEG, OR 3.19, 95% CI 2.03–5.05; without PEG, OR 2.11, 95% CI 1.04–4.23), pulmonary edema (OR 3.71, 95% CI 1.29–12.33), and DVT (OR 5.6, 95% CI 1.86–21.02), but not ICH volume or GCS. Infected patients had higher discharge mortality (16% vs. 8%, p=0.001) and worse 3-month outcomes (mRS≥3, 80% vs. 51%, p<0.001). Infection was an independent predictor of poor 3-month outcome (OR 2.6, 95% CI 1.8–3.9). Conclusions There are identifiable risk factors for infection after ICH, and infections predict poor outcomes.

show abstract

“…Endemic goiters are seen in both mountainous (New Guinea) and non-mountainous regions of Africa (Cameroun, Northern Zaire, Central Africa Republic, Uganda, and Rwanda). The prevalence rates of endemic goiters in Africa range from 1% to 90% [19]. None of these common textbooks made reference to any of the above facts.…”

Section: Areas Of Lapses In Physiology Textbook For Africamentioning

confidence: 99%

Common Physiology Textbooks Used in Nigerian Medical Schools-Need for a Broad-Based Review

Abi¹,

Oi²

2017

nat Physiol

View full text Add to dashboard Cite

The future of medical education is highly dependent on the quality of teaching tools employed by the educators. Textbooks are vital tools for teaching as they are valuable resources in the process of education. The basic medical sciences forms the foundation for medical training, and Physiology education is key. Nigerian (and indeed African) medical instructors are highly dependent on the developed world for the textbooks and research materials they employ in training their students. They common Physiology textbooks they use are mostly by non-African authors. These textbooks as beautiful and voluminous as they appear fail to fully capture information that reflect some of the pathophysiological peculiarities of the Nigerian/African population. Such an information gap has the capacity of creating a disconnect between the actual knowledge acquired in school and the practical situation present in the society. Considering the current paucity of research work from local authors there is need for more pro-activeness from indigenous researchers to bridge such gaps. Both government and private sector participation is also needed towards supporting the writing of physiology textbooks with a broader all-encompassing approach. This is a step that can pave way for an academic revolution not only in Nigeria but in the entire African continent.

show abstract

Race‐specific WBC and neutrophil count reference intervals

Cited by 81 publications

References 15 publications

Race-related health disparities and biological aging: Does rate of telomere shortening differ across blacks and whites?

Race-related health disparities and biological aging: Does rate of telomere shortening differ across blacks and whites?

Infection After Intracerebral Hemorrhage

Common Physiology Textbooks Used in Nigerian Medical Schools-Need for a Broad-Based Review

Contact Info

Product

Resources

About