Racemic 2,3,4-Triacyloxybutylarsonic Acids: A New Class of Arsonolipids with Three Acyl Chains

This article describes the preparation of the unnatural arsonolipids 7-9, pseudo arsonolipids 10 and 11, and arsinolipids 12-14 (Fig. 3). Their preparation was motivated by the unique properties of the arsenic compared to phosphorus atom of the -AsO 3 H 2 and >AsO 2 H groups. It was anticipated that these lipids will show interesting physical, chemical, biochemical and biological properties. Two key points in their preparation have been identified and studied: the preparation of the precursor hydroxy-containing arsonic and arsinic acids and their subsequent acylation to the corresponding arsono-and arsinolipids. The most intensively studied were the arsonolipids 7 which showed quite interesting physical properties forming in water super structures and interacted with carbonic anhydrase and phospholipase A 2 . They formed arsonoliposomes either in the absence or in the presence of cholesterol and a phospholipid. The latter arsonoliposomes alone, i.e. in the absence of a trapped drug, revealed quite promising selective toxicity against protozoal parasites, various cancer cells in vitro and prostate cancer in vivo.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Racemic 2,3,4-Triacyloxybutylarsonic Acids: A New Class of Arsonolipids with Three Acyl Chains

Cited by 2 publications

References 38 publications

Esterification equilibrium constants of arsonic and arsinic acids

Esterification equilibrium constants of arsonic and arsinic acids

Arsonolipids, pseudo arsonolipids, arsinolipids and arsonoliposomes: Preparations, biophysical, biochemical and biological aspects

Contact Info

Product

Resources

About