Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa

Liu, Dingquan; Mao, Shui-Chun; Zhang, Haiyan; Yu, Xiaoqing; Feng, Mei-Tang; Wang, Bin; Liu, Feng; Guo, Yue‐Wei

doi:10.1016/j.fitote.2013.08.014

Cited by 75 publications

(49 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From C. racemosa we can also find two prenylated p -xylenes [32] 18 and 19 and racemosins A 20 and B 21 [33] (Figure 5). …”

Section: Structural Characterization and Biological Activitymentioning

confidence: 99%

“…Compound 22 showed significant neuroprotection (14.6% increase in cell viability) at the concentration of 10 μM, while compounds 20 and 21 showed moderate/weak neuroprotective activity with 5.5% and 8.1% increase in cell viability (10 μM), respectively, when compared to EGCG (epigallocatechin gallate), 16.57% increase at 10 μM) as the positive control [33]. …”

Section: Structural Characterization and Biological Activitymentioning

confidence: 99%

See 1 more Smart Citation

Secondary Metabolites and Biological Activity of Invasive Macroalgae of Southern Europe

et al. 2018

View full text Add to dashboard Cite

In this review a brief description of the invasive phenomena associated with algae and its consequences on the ecosystem are presented. Three examples of invasive algae of Southern Europe, belonging to Rodophyta, Chlorophyta, and Phaeophyta, were selected, and a brief description of each genus is presented. A full description of their secondary metabolites and biological activity is given and a summary of the biological activity of extracts is also included. In Asparagopsis we encounter mainly halogenated compounds. From Caulerpa, several terpenoids and alkaloids were isolated, while in Sargassum, meroterpenoids prevail.

show abstract

“…From C. racemosa we can also find two prenylated p -xylenes [32] 18 and 19 and racemosins A 20 and B 21 [33] (Figure 5). …”

Section: Structural Characterization and Biological Activitymentioning

confidence: 99%

Section: Structural Characterization and Biological Activitymentioning

confidence: 99%

Secondary Metabolites and Biological Activity of Invasive Macroalgae of Southern Europe

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Different marine organisms, including macroalgae, provide numerous unique and intriguing bisindole alkaloids, which exhibit excellent bioactivities, thus attracting great interest from researchers [72,73]. De Souza et al .…”

Section: Neuroprotective Compounds From Macroalgaementioning

confidence: 99%

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

2014

View full text Add to dashboard Cite

Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases.

show abstract

“…Moreover, some metabolites such as caulerpin [10], caulersin [11 -14], and caulerpenyne [15], have brought great attention as examples for structure elucidation and total synthesis due to their unusual structural features and striking pharmcological properties [16 -18]. As part of our ongoing research on biologically active substances from Chinese marine algae, we have recently investigated the green alga Caulerpa racemosa, resulting in the discovery of three novel degraded bisindole alkaloids: caulerchlorin and racemosins A and B [7,19]. Our continuing studies on the same specimen led to the isolation of another novel minor bisindole alkaloid, racemosin C (1), characterized by an 8-hydroxy-2,4,6-cyclooctatrienone unit fused with two indole systems, along with one known related metabolite, caulersin (2) (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa

Yang

Liu

Liang

et al. 2014

Journal of Asian Natural Products Research

Self Cite

View full text Add to dashboard Cite

A novel minor bisindole alkaloid, racemosin C (1), characterized by a naturally unprecedented 8-hydroxy-2,4,6-cyclooctatrienone ring fused with two indole systems, was isolated from the green alga Caulerpa racemosa, together with one known related metabolite, caulersin (2). The structure of 1 was elucidated on the basis of extensive spectroscopic analysis, and by comparison with the data of related known compounds. A plausible biosynthetic pathway of 1 was proposed. Compounds 1 and 2 exhibited significant PTP1B inhibitory activity with IC50 values of 5.86 ± 0.57 and 7.14 ± 1.00 μM, respectively, compared with the positive control oleanolic acid (IC50 = 3.03 ± 0.20 μM). On the basis of the data obtained, the Caulerpa bisindole alkaloids may be considered as a new class of PTP1B inhibitors.

show abstract

Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa

Cited by 75 publications

References 27 publications

Secondary Metabolites and Biological Activity of Invasive Macroalgae of Southern Europe

Secondary Metabolites and Biological Activity of Invasive Macroalgae of Southern Europe

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa

Contact Info

Product

Resources

About