Racemozse neurocysticercosis

Wiwanitkit, Viroj

doi:10.1177/1971400915621326

Cited by 1 publication

(1 citation statement)

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“…remark that “Neurosyphilis should be a part of the differential diagnosis of every patient showing cognitive deterioration and behavior disturbances,” a sentiment supported by other clinicians 67 . The parasitic infection cysticercosis caused by larvae of Taenia solium is known to cause dementia in developing countries, and timely initiation of proper treatment results in favorable neurologic outcomes—“reversible dementia.” 68,69 Importantly, a handful of cases have been reported in which brain infections with Cryptococcus spp. “masqueraded” as AD, but remitted upon appropriate antifungal therapy, 70–73 holding promise that at least some AD cases may be amenable to therapeutic intervention.…”

Section: Introductionmentioning

confidence: 99%

Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease

Lathe

Schultek²,

Balin

et al. 2023

Alzheimer's & Dementia

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Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD brains. There is a need for a consensus methodology; the Alzheimer's Pathobiome Initiative aims to perform comparative molecular analyses of microbes in post mortem brains versus cerebrospinal fluid, blood, olfactory neuroepithelium, oral/nasopharyngeal tissue, bronchoalveolar, urinary, and gut/stool samples. Diverse extraction methodologies, polymerase chain reaction and sequencing techniques, and bioinformatic tools will be evaluated, in addition to direct microbial culture and metabolomic techniques. The goal is to provide a roadmap for detecting infectious agents in patients with mild cognitive impairment or AD. Positive findings would then prompt tailoring of antimicrobial treatments that might attenuate or remit mounting clinical deficits in a subset of patients.

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Section: Introductionmentioning

confidence: 99%