Racial and ethnic differences in experimental pain sensitivity: systematic review and meta-analysis

Kim, Hee Jun; Yang, Gee Su; Greenspan, Joel D.; Downton, Katherine; Griffith, Kathleen A.; Renn, Cynthia L.; Johantgen, Meg; Dorsey, Susan G.

doi:10.1097/j.pain.0000000000000731

Cited by 187 publications

(146 citation statements)

References 62 publications

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“…Differences in demographic characteristics-such as age, gender, BMI, and race-have been shown to lead to variability of pain sensibility. [35][36][37][38] In our present work, we also demonstrated that demographic characteristics were indispensable predictors of pain thresholds. EPT and PPT are often used in quantitative assessment of pain sensitivity in clinical studies.…”

Section: Discussionsupporting

confidence: 76%

COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity

Yin

Xiong

et al. 2020

Mol Pain

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This cross-sectional study investigated whether the catechol-O-methyltransferase (COMT) gene acts as a significant regulator of pain signaling pathways, regulates b-endorphin, and contributes to ethnic differences in pain sensitivity. One-hundred-sixty healthy subjects were enrolled in this study, with Han and Uyghur groups each consisting of 80 participants. Subjects went through six pain threshold experiments. From venous blood, COMT polymorphisms were genotyped, and serum b-endorphin levels were measured. Bivariate correlation analysis and multiple linear regression were used to identify the relationships among genotypes or b-endorphin levels and different types of pain thresholds. Han and Uyghur ethnic differences were determined in terms of acute-pressure pain-perception thresholds, blunt-pressure pain-perception thresholds, blunt-pressure pain-tolerance thresholds, electric pain-tolerance thresholds, b-endorphin levels, and distributions of rs4680 and rs4633 COMT polymorphisms. b-endorphin levels did not correlate with COMT rs4680 or rs4633 genotypes in both Han and Uyghur. Statistical predictors for a lower pain-threshold performance included being young, Uyghur, female, and having a low body mass index, low b-endorphin level, and the rs4680 GA or GG allele. There is the significant difference in pain sensitivity between healthy Han and Uyghur. COMT gene variants and b-endorphin levels contribute to ethnic differences in pain sensitivity.

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Section: Discussionsupporting

confidence: 76%

COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity

Yin

Xiong

et al. 2020

Mol Pain

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“…Race/ethnic differences in clinical and experimental pain have been widely documented , and a growing literature has recognized resilience as an important resource for individuals with chronic pain . Expanding on prior research, our study provides evidence regarding the influence of psychosocial resilience on pain and functioning among adults with knee OA and is the first to examine whether these relationships are differentially expressed across race/ethnicity.…”

Section: Discussionmentioning

confidence: 80%

“…Racial/ethnic disparities in pain and disability are widely reported as non‐Hispanic blacks (NHBs) experience more frequent, severe, and disabling pain relative to non‐Hispanic whites (NHWs) . Moreover, several studies have found that NHBs report greater experimental pain sensitivity to a number of quantitative sensory testing methods when compared with NHWs . These effects also extend to OA, as NHBs experience higher rates of symptomatic and radiographic OA , report greater average pain severity, and have higher levels of disability than NHWs .…”

Section: Introductionmentioning

confidence: 99%

Race/Ethnicity Moderates the Association Between Psychosocial Resilience and Movement‐Evoked Pain in Knee Osteoarthritis

Bartley

Hossain

Gravlee

et al. 2019

ACR Open Rheumatology

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ObjectiveRacial/ethnic disparities in pain are well‐recognized, with non‐Hispanic blacks (NHBs) experiencing greater pain severity and pain‐related disability than non‐Hispanic whites (NHWs). Although numerous risk factors are posited as contributors to these disparities, there is limited research addressing how resilience differentially influences pain and functioning across race/ethnicity. Therefore, this study examined associations between measures of psychosocial resilience, clinical pain, and functional performance among adults with knee osteoarthritis (OA), and assessed the moderating role of race/ethnicity on these relationships.MethodsIn a secondary analysis of the Understanding Pain and Limitations in Osteoarthritic Disease (UPLOAD‐2) study, 201 individuals with knee OA (NHB = 105, NHW = 96) completed measures of resilience (ie, trait resilience, optimism, positive well‐being, social support, positive affect) and clinical pain, as well as a performance‐based measure assessing lower‐extremity function and movement‐evoked pain.ResultsBivariate analyses showed that higher levels of psychosocial resilience were associated with lower clinical pain and disability and more optimal physical functioning. NHBs reported greater pain and disability, poorer lower‐extremity function, and higher movement‐evoked pain compared with NHWs; however, measures of psychosocial resilience were similar across race/ethnicity. In moderation analyses, higher optimism and positive well‐being were protective against movement‐evoked pain in NHBs, whereas higher levels of positive affect were associated with greater movement‐evoked pain in NHWs.ConclusionOur findings underscore the importance of psychosocial resilience on OA‐related pain and function and highlight the influence of race/ethnicity on the resilience‐pain relationship. Treatments aimed at targeting resilience may help mitigate racial/ethnic disparities in pain.

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“…A relation between perception of pain and ethnicity has been proposed (Kim et al 2017). Of the people living in € Orebro County in 2015, 248 474 (85.4%) were born in Sweden and 42 538 (14.6%) were born abroad (www.SCB.se).…”

Section: Characteristics and Impact Of Painmentioning

confidence: 99%

The frequency and characteristics of pain and discomfort associated with root filled teeth: a practice‐based study

et al. 2019

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Aim To (i) investigate the frequency and characteristics of pain and discomfort associated with root filled teeth in adult patients regularly attending the Public Dental Service in Örebro County, Sweden; (ii) assess the association between symptoms and clinical and radiographic findings; and (iii) explore the impact of pain and discomfort from root filled teeth on daily life. Methodology Patient records of adult patients (≥20 years) scheduled for routine check‐ups in April 2015 were screened to identify individuals with root filled teeth; all patients with ≥1 root filled tooth were asked to participate. The examination comprised of clinical and radiographic examinations and questionnaires on general health, on pain symptoms from root filled teeth and on the impact of pain on daily activities. In a general estimating equation (GEE), examination findings and patient‐related factors were independently analysed in relation to the outcome ‘presence of pain’. Results In total, 550 patients with 1256 root filled teeth participated. Fifty‐three patients (9.6%) experienced pain or discomfort from 62 (4.9%) root filled teeth. Lower age, percussion tenderness and apical tenderness were significantly associated with pain (P > 0.001 to P = 0.044). The average pain intensity was 2.1 on a (0–10) Numeric Rating Scale, and average duration was 28.4 months. The impact on daily life was low. Conclusions On average, pain associated with root filled teeth was of mild intensity, >2 years of duration and had low impact on daily life. Although the significantly associated clinical findings may indicate apical periodontitis as the most probable explanation in some teeth, the origin of pain from root filled teeth remains partly unexplained.

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Racial and ethnic differences in experimental pain sensitivity: systematic review and meta-analysis

Cited by 187 publications

References 62 publications

COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity

COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity

Race/Ethnicity Moderates the Association Between Psychosocial Resilience and Movement‐Evoked Pain in Knee Osteoarthritis

The frequency and characteristics of pain and discomfort associated with root filled teeth: a practice‐based study

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