Racial and Ethnic Disparities in Adverse Drug Events: A Systematic Review of the Literature

Baehr, Avi; Peña, Juliet C.; Hu, Dale J.

doi:10.1007/s40615-015-0101-3

Cited by 53 publications

(46 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent systematic review found no consistent relationship between race and ADRs in general but noted that certain racial groups may be at higher risk for ADRs due to certain classes of agents (18). Asians were found to be higher risk for ADRs from oral anticoagulants whereas blacks were at higher risks from antidiabetic agents and whites from opiate analgesics (18). In a study of United States Vital Statistics, deaths due to ADRs were significantly more frequent in African-Americans than Caucasians, Hispanics, or Asians (19).…”

Section: Discussionmentioning

confidence: 99%

Idiosyncratic Drug Induced Liver Injury in African–Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians

Chalasani

Reddy

Fontana

et al. 2017

American Journal of Gastroenterology

View full text Add to dashboard Cite

Background Idiosyncratic drug induced liver injury (DILI) is a rare but potentially serious liver disorder and a major cause of significant liver injury. Limited data exist on racial differences in DILI incidence, presentation and course. Aim & Methods We compared the causative agents, clinical features and outcomes of DILI among self-described African-Americans and non-Hispanic whites (Caucasians) enrolled in the DILIN Prospective Study. Individuals with definite, highly likely, or probable DILI enrolled between Sept 2004 and Feb 2016 were included in this analysis. Results 144 African-Americans and 841 Caucasian patients met the eligibility criteria. Causal medications varied by race: trimethoprim/sulfamethoxazole being the most common cause among African-Americans (7.6% vs 3.6%) followed by methyldopa (4% vs <1%), phenytoin (5% vs <1%), isoniazid (4% vs 4%) and amoxicillin/clavulanate (4.1% vs 13.4%). The severity of illness, however, tended to be greater in African-Americans than Caucasians as determined by peak mean bilirubin (14.3 vs 12.8 mg/dL), INR (1.9 vs 1.6) and DILIN severity score (3.0 vs 2.6). The frequency of severe cutaneous reactions was significantly higher in African-Americans (2.1 vs. 0.36% in Caucasians, p=0.048). African-Americans also had higher rates of hospitalization (76.7% vs 57.6%, p<0.001), liver transplantation or liver related death by 6 months (10.2% vs 5.8%, p=0.02 after controlling for selected covariates) and chronic DILI (24% vs. 16%, p=0.06). Conclusions The most common DILI causative agents differ between African-Americans and Caucasians. African-Americans are more likely to have severe cutaneous reactions and more severe liver injury leading to worse outcomes, including death and liver transplant. [Word Count 250]

show abstract

Section: Discussionmentioning

confidence: 99%

Idiosyncratic Drug Induced Liver Injury in African–Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians

Chalasani

Reddy

Fontana

et al. 2017

American Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…The evidence relating to ADEs among ethnic minorities was mixed and was observed to depend on contextual features such as geographical, genetic and cultural features [35,57,59]. Metersky White et al [12] 2012 Australia Primary Focus groups (n = 2) with…”

Section: Review Q 2: What Is the Evidence For Patient Safety Events Imentioning

confidence: 99%

“…• Chinese participants had doubts about the their systematic review observed that Asians were more prone to ADEs related to anticoagulants such as bleeding and African American to ADEs relating to diabetes agents such as hypoglycaemia [35]. The term Asian represented combined Asian/Pacific Islander group but authors did not specify any specific ethnic minority group from Asia.…”

Section: Review Q 2: What Is the Evidence For Patient Safety Events Imentioning

confidence: 99%

The safety of health care for ethnic minority patients: a systematic review

Chauhan

Walton

Manias

et al. 2020

Int J Equity Health

150

157

View full text Add to dashboard Cite

Introduction: Evidence to date indicates that patients from ethnic minority backgrounds may experience disparity in the quality and safety of health care they receive due to a range of socio-cultural factors. Although heightened risk of patient safety events is of key concern, there is a dearth of evidence regarding the nature and rate of patient safety events occurring amongst ethnic minority consumers, which is critical for the development of relevant intervention approaches to enhance the safety of their care. Objectives: To establish how ethnic minority populations are conceptualised in the international literature, and the implications of this in shaping of our findings; the evidence of patient safety events arising among ethnic minority healthcare consumers internationally; and the individual, service and system factors that contribute to unsafe care. Method: A systematic review of five databases (MEDLINE, PUBMED, PsycINFO, EMBASE and CINAHL) were undertaken using subject headings (MeSH) and keywords to identify studies relevant to our objectives. Inclusion criteria were applied independently by two researchers. A narrative synthesis was undertaken due to heterogeneity of the study designs of included studies followed by a study appraisal process. Results: Forty-five studies were included in this review. Findings indicate that: (1) those from ethnic minority backgrounds were conceptualised variably; (2) people from ethnic minority backgrounds had higher rates of hospital acquired infections, complications, adverse drug events and dosing errors when compared to the wider population; and (3) factors including language proficiency, beliefs about illness and treatment, formal and informal interpreter use, consumer engagement, and interactions with health professionals contributed to increased risk of safety events amongst these populations. Conclusion: Ethnic minority consumers may experience inequity in the safety of care and be at higher risk of patient safety events. Health services and systems must consider the individual, inter-and intra-ethnic variations in the nature of safety events to understand the where and how to invest resource to enhance equity in the safety of care. Review registration: This systematic review is registered with Research Registry: reviewregistry761.

show abstract

“…Women were classified as "food secure" if they reported no more than 2 food-insecure conditions and "food insecure" if they reported 3 or more. Financial difficulties and housing disrepair were measured using the Survey of Income and Program Participation [16]. Difficulties paying bills was assessed using the questions (1) "Have you had serious financial problems or been unable to pay monthly bills, rent, or mortgage during the past 12 months?…”

Section: Psychosocial Stressorsmentioning

confidence: 99%

Predictors of Gestational Weight Gain in a Low-Income Hispanic Population: Sociodemographic Characteristics, Health Behaviors, and Psychosocial Stressors

Dolin

Gross

Deierlein

et al. 2020

IJERPH

View full text Add to dashboard Cite

Hispanic women have a higher prevalence of weight associated complications in pregnancy. This ethnic disparity is likely related to behavior patterns, social circumstances, environmental exposures, and access to healthcare, rather than biologic differences. The objective was to determine associations between sociodemographic characteristics, health behaviors, and psychosocial stressors and gestational weight gain (GWG) in low-income Hispanic women. During pregnancy, information on sociodemographic characteristics, health behaviors, and psychosocial stressors were collected. Linear regression estimated mean differences in GWG by selected predictors. Multinomial logistic regression estimated odds of inadequate and excessive GWG by selected predictors. Five-hundred and eight women were included, 38% had inadequate and 28% had excessive GWG; 57% with a normal pre-pregnancy BMI had inadequate GWG. Compared to women with normal BMI, women with overweight or obesity were more likely to have excessive GWG (aRRR = 1.88, 95% CI: 1.04, 3.40 and aRRR = 1.98, 95% CI: 1.08, 3.62, respectively). Mean total GWG was higher among women who were nulliparous (ß = 1.34 kg, 95% CI: 0.38, 2.29) and those who engaged in ≥3 h of screen time daily (ß = 0.98 kg, 95% CI: 0.02, 1.94), and lower among women who were physically active during pregnancy (ß = −1.00 kg, 95% CI: −1.99, −0.03). Eating breakfast daily was associated with lower risk of inadequate GWG (aRRR = 0.47, 95% CI: 0.26, 0.83). Depressive symptoms and poor adherence to dietary recommendations were prevalent, but none of the psychosocial or dietary variables were associated with GWG. In this cohort of primarily immigrant, low-income, Hispanic women, there were high rates of poor adherence to diet and physical activity recommendations, and a majority of women did not meet GWG guidelines. Modifiable health behaviors were associated with GWG, and their promotion should be included in prenatal care.

show abstract

Racial and Ethnic Disparities in Adverse Drug Events: A Systematic Review of the Literature

Cited by 53 publications

References 53 publications

Idiosyncratic Drug Induced Liver Injury in African–Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians

Idiosyncratic Drug Induced Liver Injury in African–Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians

The safety of health care for ethnic minority patients: a systematic review

Predictors of Gestational Weight Gain in a Low-Income Hispanic Population: Sociodemographic Characteristics, Health Behaviors, and Psychosocial Stressors

Contact Info

Product

Resources

About