Racial and Ethnic Inequality in Survival Outcomes of Women With Triple Negative Breast Cancer

Abstract

Triple-negative breast cancer (TNBC) is the most lethal group of breast cancers. Socioeconomic factors may contribute to differences in survival rates. This study aims to identify racial/ethnic disparities in five-year survival rates among women affected by TNBC in the United States. MethodsThis retrospective study analyzed data from the 2010-2016 Surveillance, Epidemiology, and End Results Program database. Patients with a primary malignancy of triple-negative breast cancer were included in this study. Cancer-specific survival was measured at five years post-diagnosis. Cox regression models were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (CI). ResultsFrom 2010-2016, there were 26,963 women with a primary diagnosis of TNBC. After adjustment for age, insurance, marital status, stage, and surgery type, Hispanic women had the highest hazard of death when compared to White women (adjusted (adj) HR, 1.14, p<0.001). Further, non-Hispanic Black women also had a lower survival probability when compared to White women (adj HR, 1.06, p=0.002). ConclusionThis study reveals that Hispanic women had the highest hazard of death when compared to White women. As TNBC is the most fatal breast cancer, future studies should investigate socioeconomic factors that may worsen prognosis of this disease.

Premenopausal Breast Cancer: Comparative analysis of clinical, pathological features and survival with postmenopausal breast cancer from an Indian cohort

“…This study reported that higher proportion of TNBC tumors in postmenopausal patients and their association with favourable tumor characteristics and better DFS compared to premenopausal patients [29] which is contrary to our observations. Disparities in TNBC outcomes have been reported based on race and ethnicity in multiple studies earlier [30][31][32]. Younger median age of our cohort and ethnicity-based differences between Indian and Japanese women might have contributed to the observed difference.…”

A comparative analysis of clinicopathological features and survival between pre and postmenopausal breast cancer from an Indian cohort

“…This study reported that higher proportion of TNBC tumors in postmenopausal patients and their association with favourable tumor characteristics and better DFS compared to premenopausal patients 31 which is contrary to our observations. Disparities in TNBC outcomes have been reported based on race and ethnicity in multiple studies earlier [32][33][34] . Younger median age of our cohort and ethnicity-based differences between Indian and Japanese women might have contributed to the observed difference.…”

Disparities in Receipt of National Comprehensive Cancer Network Guideline-Adherent Care and Outcomes among Women with Triple-Negative Breast Cancer by Race/Ethnicity, Socioeconomic Status, and Insurance Type

“…Adherence to evidence-based management improves outcomes in patients with breast cancer [7,8]. A few studies have looked at disparities in treatment and outcomes in triple-negative breast cancer patients [9,10]. However, the available studies did not design a treatment algorithm based on GAC by cancer stage.…”