Racial and geographic disparities in reconstructive procedures following melanoma resection

Hauc, Sacha C.; Rodriguez, Jennifer; Long, Aaron S.; Matejac, Kirby; Aboukhater, Layla M.; Ihnat, Jacqueline; Junn, Alexandra; Dinis, Jacob; Phillips, Sarah; Alperovich, Michael

doi:10.1016/j.bjps.2022.08.031

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…24,25 Another study found similar results that rural patients were less likely to undergo complex reconstructive procedures for melanoma. 26 One potential explanation for the decreased rates of surgery could be the reduced rural surgical workforce. 27 In recent years, there has been a decreasing number of surgeons in rural areas.…”

Section: Discussionmentioning

confidence: 99%

Rural Melanoma Patients Have Less Surgery and Higher Melanoma-Specific Mortality

Hernandez,

Benck,

Huerta

et al. 2023

The American Surgeon™

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Background Melanoma causes most skin cancer–related deaths, and disparities in mortality persist. Rural communities, compared to urban, face higher levels of poverty and more barriers to care, leading to higher stage at presentation and shorter survival in melanoma. To further evaluate these disparities, we sought to assess the association between rurality and melanoma cause-specific mortality and receipt of recommended surgery in a national cohort. Methods Patients with primary non-ocular, cutaneous melanoma from the SEER database, 2000-2017, were included. Outcomes included melanoma-specific survival and receipt of recommended surgery. Rurality was based on Rural-Urban Continuum Codes. Variables included age, sex, race, ethnicity, income, and stage. Multivariate regression models assessed the effect of rurality on survival and receipt of recommended surgery. Results 103,606 patients diagnosed with non-ocular cutaneous primary melanoma met criteria during this period. 93.3% ( n = 96620) were in urban areas and 6.7% ( n = 6986) were in rural areas. On multivariate regression controlling for age, sex, race, ethnicity, and stage patients living in a rural area were less likely to receive recommended surgery (aOR .52, 95% CI: .29-.90, P = .02) and had increased hazard of melanoma-specific mortality (aHR 1.19, 95% CI: 1.02-1.40, P = .03) even after additionally controlling for surgery receipt. Conclusion Using a large national cohort, our study found that rural patients were less likely to receive recommended surgery and had shorter melanoma cause-specific survival. Our findings highlight the importance of access to cancer care in rural areas and how this ultimately effects survival for these patients.

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Section: Discussionmentioning

confidence: 99%

Rural Melanoma Patients Have Less Surgery and Higher Melanoma-Specific Mortality

Hernandez,

Benck,

Huerta

et al. 2023

The American Surgeon™

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TPC2: From Blond Hair to Melanoma?

Abrahamian,

Ouologuem,

Tang

et al. 2024

Cancers

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Two-pore channel 2 (TPC2) is expressed in endolysosomes throughout the human body, as well as in melanosomes of melanocytes. Melanocytes produce pigment, i.e., melanin, which determines hair and skin color but also protects from UV light. Extensive exposure to UV light is one of the major risk factors for the development of melanoma, which develops from pigment-producing cells, i.e., melanocytes. In recent years, several human TPC2 single nucleotide polymorphisms have been identified to increase the likelihood of carriers presenting with blond hair and hypopigmentation. These variants were all characterized as gain-of-function versions of TPC2. Vice versa, the loss of function of TPC2 increases melanin production and reduces cancer hallmarks such as proliferation, migration, invasion, tumor growth, and metastasis formation. The activity of TPC2 is controlled in a complex manner, with several endogenous ligands as well as a number of interacting proteins being involved. We will discuss here the role of TPC2 in pigmentation and its potential to impact melanoma development and progression and highlight recent findings on Rab7a as an enhancer of TPC2 activity.

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Racial and geographic disparities in reconstructive procedures following melanoma resection

Cited by 2 publications

References 35 publications

Rural Melanoma Patients Have Less Surgery and Higher Melanoma-Specific Mortality

Rural Melanoma Patients Have Less Surgery and Higher Melanoma-Specific Mortality

TPC2: From Blond Hair to Melanoma?

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