Racial Differences in Macular Thickness in Healthy Eyes

Asefzadeh, Baharak; Cavallerano, Anthony; Fisch, Barry

doi:10.1097/opx.0b013e318157a6a0

Cited by 73 publications

(63 citation statements)

References 24 publications

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“…Asian and black subjects have thinner maculas compared with white subjects. 7,57 The subjects in the present study and that of Huang et al's were Asians, and both studies found thinner maculas. Our total retinal thickness (Retina 1) was in good agreement with the findings of Koozekanani et al who measured the retinal thickness as 274 μm over a similar region.…”

Section: Discussionsupporting

confidence: 51%

Quantitative analysis of the intraretinal layers and optic nerve head using ultra-high resolution optical coherence tomography

et al. 2012

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Abstract. This study is designed to test the repeatability of the quantitative analysis of intraretinal layer thickness and cup-disc ratio of the optic nerve head using ultra-high resolution optical coherence tomography (UHR-OCT). Group A, containing 23 eyes of 12 healthy subjects, was imaged twice and group B, containing eight eyes of four subjects, was imaged three times. Intraretinal layers were segmented manually and the cup-to-disc ratio of the optic nerve head was analyzed. Custom-built automatic segmentation software was also used to segment a set of images for comparison. A total of nine intraretinal layers were visualized and extracted manually. With group A, the central foveal thickness was 186.4 AE 15.9 μm (mean AE SD). The average retinal thickness was 296.4 AE 21.3 μm. The best repeatability, obtained when two repeated scans were taken, was obtained for the outer nuclear layer followed by the ganglion cell layer, the inner nuclear layer, the retinal nerve fiber layer and the worst was obtained for the outer segment. The intraclass correlation ranged from 0.824 to 0.997. The coefficients of repeatability ranged from 3.24 to 18.3 μm, corresponding to 1.47% to 26.20%. With group B, high interclass correlations were found and the automatic segmentation results were compatible with the manual results. Our results indicated that more retinal features might be imageable using UHR-OCT.

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Section: Discussionsupporting

confidence: 51%

Quantitative analysis of the intraretinal layers and optic nerve head using ultra-high resolution optical coherence tomography

et al. 2012

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“…There were no differences in P1-IT, but P1 amplitude was greater in Canadian subjects, and this was attributed to the lower axial length in comparison with Chinese eyes [15]. In addition, several studies performed by SD-OCT have reported significant differences in retinal thickness between subjects of different ethnicities [13,17,18,19]. In our study all the patients were Caucasian, thus excluding ethnicity as a potential confounding factor.…”

Section: Discussionmentioning

confidence: 59%

Development of a Normative Database for Multifocal Electroretinography in the Context of a Multicenter Clinical Trial

et al. 2017

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Purpose: The aim of this study is to present the largest normative database using multifocal electroretinography (mfERG) in the context of a multicenter clinical trial. Methods: This investigational study included 156 eyes from 78 Caucasian subjects aged 45-70 years without known ophthalmic disease or diabetes mellitus; the subjects were recruited from 11 clinical sites in the setting of the EUROCONDOR project. Standardized mfERG acquisition (103 hexagons per eye) was established based on the International Society of Clinical Electrophysiology in Vision. At least one technician per site received both specialized training and certification. The main variables that could have influenced the results were considered in the analyses. Results: The normative database was based on 111 eyes. The overall mean P1-implicit time (IT) was 33.94 ± 1.70 ms, and the mean P1 amplitude was 30.58 ± 5.20 nV/deg². Age and gender were independently related to predictors of P1-IT but not of P1 amplitude. The responses that were averaged for the 6 rings showed a longer P1-IT time in the fovea, decreasing progressively to the parafovea and perifovea. By contrast, P1 amplitude values sharply decreased with retinal eccentricity. Conclusions: This normative database can be used as a comparative index of expected normal values in the clinical setting and for examining the effect of studies testing neuroprotective agents.

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“…[14][15][16] The main difference between the current approach and previous approaches is the use of a mathematical model of the foveal shape 11 instead of the direct measurement using the OCT devices, and the specific comparison of features important for the analysis of glaucomatous damage in the macular (namely superior and inferior hemifield asymmetry).…”

Section: Discussionmentioning

confidence: 99%

Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region

Sepulveda

Turpin

McKendrick

2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Sepulveda JA, Turpin A, McKendrick AM. Individual differences in foveal shape: feasibility of individual maps between structure and function within the macular region. Invest Ophthalmol Vis Sci. 2016;57:4772-4778. DOI:10.1167/ iovs.16-19288 PURPOSE. Recently in glaucoma, different mapping schemes to combine structural and functional information within the macula have been proposed. This paper aims to investigate whether the changes in foveal shape parameters are important in the mapping between structure and function within the macular region.METHODS. Twenty younger adults (aged 24-to 33-years old) and 10 older adults (aged 62-to 76-years old) participated. On each subject, four foveally-centered radial spectral-domain optical coherence tomography (SD-OCT) scans with 458 of separation between each scan were acquired. After scan acquisition, foveal shape was extracted by fitting a previously proposed model that has been used to customize structure-function mapping in the macular region. Three parameters were obtained from the scans and then compared: the central thickness, the maximum thickness, and the radius.RESULTS. There were significant differences in the foveal shape parameters between subjects. There was no main effect of the scan axis for the central thickness; however, there was an interaction between the scan axis and maximum thickness and between the scan axis and radius. With respect to the effect of age, we did not find a main effect for the central thickness, the maximum thickness or the radius, although this parameter approached statistical significance. CONCLUSIONS.In our study, we demonstrated that the foveal shape is different for different subjects, but predictable superiorly and inferiorly within an individual. Our study highlights features important for the development of individually customized structure-function maps for the investigation of glaucomatous damage in the macular region.

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Racial Differences in Macular Thickness in Healthy Eyes

Abstract: Retinal thickness as measured by Stratus OCT in the fovea and macula is significantly thinner in blacks compared with age-matched whites. Larger multiracial prospective studies are needed to confirm these results and to evaluate the need for race-specific normative values.

Cited by 73 publications

References 24 publications

Quantitative analysis of the intraretinal layers and optic nerve head using ultra-high resolution optical coherence tomography

Quantitative analysis of the intraretinal layers and optic nerve head using ultra-high resolution optical coherence tomography

Development of a Normative Database for Multifocal Electroretinography in the Context of a Multicenter Clinical Trial

Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region

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