Racial differences in testicular cancer in the United States: descriptive epidemiology

Abstract

Background Testicular cancer (TC) is the most common malignancy in young adult men, and in many countries the incidence rates of testicular cancer have been increasing since the middle of the twentieth century. Since disease presentation and tumor progression patterns are often heterogeneous across racial groups, there may be important racial differences in recent TC trends. Methods In this study, Surveillance, Epidemiology, and End Results (SEER) data on TC patients diagnosed between 1973 and 2015 were analyzed, including the following racial/ethnic groups: non-Hispanic whites (NHW), Hispanic whites (HW), blacks, and Asians and Pacific Islanders (API). Patient characteristics, age-adjusted incidence rates, and survival were compared across racial groups. A multivariate Cox model was used to analyze the survival data of TC patients, in order to evaluate racial differences across several relevant factors, including marital status, age group, histologic type, treatment, stage, and tumor location. Results NHWs had the highest incidence rates, followed by blacks, HWs, and APIs. There were significant survival differences among the racial groups, with NHWs having the highest survival rates and blacks having the lowest. Conclusion An analysis of SEER data showed that racial differences existed among TC patients in the United States with respect to patient characteristics, incidence, and survival. The results can be useful to stakeholders interested in reducing the burden of TC morbidity and mortality.

Assessing Health-Related Quality of Life Among Survivors of Testicular Cancer: A Systematic Review

“…Minority males tend to be disproportionately affected by late-stage discovery and suffer from worse HRQoL outcomes as compared to their White counterparts ( Ghazarian et al, 2017 ; Li et al, 2020 ). For example, Black males have nearly twice the mortality rate and Latinos are projected to have the highest incidence rates of TC among all race/ethnicities by the year 2026 ( Ghazarian et al, 2017 ; Li et al, 2020 ). These data indicate a significant shift in the burden associated with TC now resides with minority males.…”

“…Even though survival rates have increased significantly over the past few decades due to advancements in treatment, disparities exist with mortality outcomes between demographic groups. For example, although White males experience the highest incidence of the disease, Black males have nearly twice the mortality rate ( Li et al, 2020 ). Further, within the next decade, Latinos are projected to have the highest incidence rates of TC among all races/ethnicities, surpassing White males ( Ghazarian et al, 2017 ).…”

The Effects of Perceived Social Support, Psychological Resilience and Coping Strategies on Life Satisfaction in Men Diagnosed with Testicular Cancer

“…For this reason, the diagnosis and treatment process of cancer is a process in which individuals need more social support and want to perceive this support at a high level. Since the life expectancy of cured testicular patients is long, minimizing the effects on long-term health and quality of life are important goals [7]. Although it is predicted that patients' psychological resilience and life satisfaction and often psychological symptoms may be observed during the treatment process of testicular cancer, there is no study conducted on this subject.…”

Genomic profile in TGCT Mexican patients reveals a potential biomarker of sensitivity to platinum-based therapy

“…Incidence and especially mortality varies throughout different ethnicities, with non-hispanic whites being the most commonly affected population in the US. Nevertheless, hispanic population is the second most affected group (Li et al, 2020). Recently, chemoresistance has been broadly studied in american non-hispanic whites, caucasians and european populations since they tend to have the highest incidence (Loveday et al, 2020).…”