Racial differences in the age-related increase in left ventricular mass in youths.

Harshfield, Gregory A.; Koelsch, David W.; Pulliam, Derrick A.; Alpert, Bruce S.; Richey, Phyllis A.; Becker, Judith A.

doi:10.1161/01.hyp.24.6.747

Cited by 24 publications

(10 citation statements)

References 34 publications

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“…Our results support the view that sodium intake correlates with target organ damage. However, the effects of sodium intake and aldosterone secretion vary according to ethnicity, genetic background, age, and socio-economic factors, all of which differed among the groups studied to date [34,35].…”

Section: Discussionmentioning

confidence: 99%

Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension

et al. 2006

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“…Although the guidelines indicated that were no significant race-related differences in chamber size, 1 other studies have reported significant racial differences in LV geometry. [8][9][10] However, diagnostic or therapeutic decisions are sometimes based on the echocardiographic results without indexing the parameters for BSA. Thus, cardiac chamber dimensional differences among races should be carefully considered when these measurements are used for making diagnostic or therapeutic decisions in individual patients.…”

Section: Cardiac Chamber Quantificationmentioning

confidence: 99%

Normal Values of Echocardiographic Parameters in Relation to Age in a Healthy Japanese Population The JAMP Study

Daimon

Watanabe

Abe

et al. 2008

Circ J

206

190

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chocardiography is now recognized as an integral diagnostic tool that enables noninvasive quantification of cardiac chamber size, ventricular mass, and function in the clinical setting. Furthermore, technological advancement in Doppler echocardiography enables quantitative assessment of ventricular diastolic function as well as systolic function. Thus, echocardiography has become an important cardiac imaging technique in a number of clinical trials evaluating the efficacy of drug treatments or new therapeutic strategies.A guideline for quantifying cardiac chamber size and function using echocardiography, and references values for Circulation Journal Vol.72, November 2008 these echocardiographic measurements, were provided by the American Society of Echocardiography in conjunction with the European Association of Echocardiography. 1 Likewise, Doppler echocardiographic criteria for assessing left ventricular (LV) diastolic function were provided by the Canadian Consensus, 2 European 3 and American Medical Association guidelines, 4 and diastolic function parameters were reported to decline gradually with age. 5 However, most of these data are derived from American and European populations and because physical 6,7 and racial 8-10 differences can influence cardiac chamber size and function, it is important to evaluate the echocardiographic parameters in other populations. Reference values based on a large Asian population have not been previously reported, although some investigators have reported these values in a small population. 11 In addition, most studies that have investigated the relationship between age and cardiac chamber size and function have focused on a few parameters and have not assessed all of them in a large population.Accordingly, we designed and conducted a multicenter study, the Japanese Normal Values for Echocardiographic Measurements Project (JAMP) study, to determine the normal values for echocardiographic measurements and evaluate the relationship between these parameters and age in a large, healthy Japanese population. J 2008; 72: 1859 -1866 (Received February 27, 2008 revised manuscript received June 11, 2008; accepted June 26, 2008; released online September 29, 2008) Circ

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“…Studies of normal and hypertensive children have found that systolic blood pressure (SBP) and LVMI are positively associated across a wide range of blood pressure values, with no clear blood pressure threshold to predict pathologically increased LVMI. [2][3][4][5][6][7][8] Studies of hypertensive children have reported prevalences of LVH that vary widely. 6 -14 Although these data suggest that children with elevated blood pressure do suffer end-organ injury, its prediction using current hypertension definitions remains uncertain.…”

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Ambulatory Blood Pressure and Left Ventricular Mass Index in Hypertensive Children

et al. 2002

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Abstract-To determine whether ambulatory blood pressure is more predictive of left ventricular hypertrophy than is casual blood pressure in hypertensive children, echocardiography and ambulatory blood pressure data from 37 untreated hypertensive children were analyzed. Left ventricular mass was calculated using the Devereux equation, left ventricular mass index was calculated as left ventricular mass (in grams)/height 2.7 (in meters), and left ventricular hypertrophy was defined as left ventricular mass index Ͼ51 g/m 2.7 . Average blood pressure, blood pressure load, and blood pressure index (average blood pressure divided by pediatric ambulatory blood pressure 95th percentile) were calculated. Left ventricular mass index was strongly correlated with 24-hour systolic blood pressure index (rϭ0.43, Pϭ0.008) and was also correlated with 24-hour systolic blood pressure (rϭ0.34, Pϭ0.037), 24-hour systolic blood pressure load (rϭ0.38, Pϭ0.020), wake systolic blood pressure load (rϭ0.37, Pϭ0.025), sleep systolic blood pressure (rϭ0.33, Pϭ0.048), and sleep systolic blood pressure load (rϭ0.38, Pϭ0.021). Left ventricular mass index did not correlate with age, weight, clinic blood pressure, or ambulatory diastolic blood pressure. The overall prevalence of left ventricular hypertrophy was 27%. The prevalence of left ventricular hypertrophy was 47% (8 of 17) in patients with both systolic blood pressure load Ͼ50% and 24-hour systolic blood pressure index Ͼ1.0, compared with 10% (2 of 20) in patients without both criteria (Pϭ0.015). These data suggest ambulatory blood pressure monitoring may be useful for the clinical assessment of hypertensive children by identifying those at high risk for the presence of end organ injury. T he most recent update from the Task Force on High Blood Pressure in Children and Adolescents 1 provided population-based 95th percentile blood pressure values in children adjusted for age, gender, and height. These pediatric normative data have guided the interpretation of blood pressure values and provided criteria for the diagnosis of hypertension in children. However, the paucity of data in children linking this statistically based definition of hypertension with evidence of hypertensive end-organ injury has created uncertainty regarding the indications for initiating antihypertensive medication in children whose blood pressure exceeds these threshold values. Because overt morbid cardiovascular events are rare in the majority of hypertensive children, attention has focused on other markers of hypertensive injury, such as increased left ventricular mass index (LVMI) and the presence of left ventricular hypertrophy (LVH). Studies of normal and hypertensive children have found that systolic blood pressure (SBP) and LVMI are positively associated across a wide range of blood pressure values, with no clear blood pressure threshold to predict pathologically increased LVMI. 2-8 Studies of hypertensive children have reported prevalences of LVH that vary widely. 6 -14 Although these data suggest that childre...

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Racial differences in the age-related increase in left ventricular mass in youths.

Cited by 24 publications

References 34 publications

Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension

Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension

Normal Values of Echocardiographic Parameters in Relation to Age in a Healthy Japanese Population The JAMP Study

Ambulatory Blood Pressure and Left Ventricular Mass Index in Hypertensive Children

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