Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment

Oliver, Kate; Enewold, Lindsey; Zhu, Kangmin; Conrads, Thomas P.; Rose, G. Scott; Maxwell, G. Larry; Farley, John H.

doi:10.1016/j.ygyno.2011.06.027

Cited by 46 publications

(42 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aggressive histology types, such as serous or clear cell adenocarcinoma, carcinosarcoma, and uterine sarcomas, have been shown to account for a disproportionate percentage of tumors seen among Black women [42,43,46,52,53]. The histopathologic features evaluated in these large population based studies typically represent the usual types of endometrial cancers, (serous, clear cell, and poorly differentiated adenocarcinomas) and may account for more advanced stage at presentation seen among Black women [42,43,47,53,54](Table 2A).…”

Section: Endometrial Cancermentioning

confidence: 99%

Gynecologic cancer disparities: A report from the Health Disparities Taskforce of the Society of Gynecologic Oncology

Collins

Holcomb

Chapman‐Davis

et al. 2014

Gynecologic Oncology

Self Cite

196

155

View full text Add to dashboard Cite

Objectives To review the extent of health disparities in gynecologic cancer care and outcomes and to propose recommendations to help counteract the disparities. Methods We searched the electronic databases PubMed and the Cochrane Library. We included studies demonstrating quantifiable differences by race and ethnicity in the incidence, treatment, and survival of gynecologic cancers in the United States (US). Most studies relied on retrospective data. We focused on differences between Black and White women, because of the limited number of studies on non-Black women. Results White women have a higher incidence of ovarian cancer compared to Black women. However, the all-cause ovarian cancer mortality in Black women is 1.3 times higher than that of White women. Endometrial and cervical cancer mortality in Black women is twice that of White women. The etiology of these disparities is multifaceted. However, much of the evidence suggests that equal care leads to equal outcomes for Black women diagnosed with gynecologic cancers. Underlying molecular factors may play an additional role in aggressive tumor biology and endometrial cancer disparities. Conclusion Gynecologic cancer disparities exist between Black and White women. The literature is limited by the lack of large prospective trials and adequate numbers of non-Black racial and ethnic groups. We conclude with recommendations for continued research and a multifaceted approach to eliminate gynecologic cancer disparities.

show abstract

Section: Endometrial Cancermentioning

confidence: 99%

Gynecologic cancer disparities: A report from the Health Disparities Taskforce of the Society of Gynecologic Oncology

Collins

Holcomb

Chapman‐Davis

et al. 2014

Gynecologic Oncology

Self Cite

196

155

View full text Add to dashboard Cite

show abstract

“…Five population-based studies and one large single-institution study documented the racial disparity in endometrial cancer histology and stage at presentation (Tables 2 and 3) [6, 7, 9, 11-13]. Though only one of these studies was a prospective analysis [7], all utilized large sample populations and reported similar rates of each cancer subtype across ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

“…In attempt to control for differences in access to care, Oliver et al evaluated racial disparities among 2,582 beneficiaries in the Department of Defense Military Health System [13]. The study did not analyze survival data but focused on the effect of an equal access environment on histologic subtype, grade, and stage at presentation.…”

Section: Introductionmentioning

confidence: 99%

Disparities in uterine cancer epidemiology, treatment, and survival among African Americans in the United States

Long

Liu

Bristow

2013

Gynecologic Oncology

145

102

View full text Add to dashboard Cite

Objective The objective of this article is to comprehensively review the scientific literature and summarize the available data regarding the outcome disparities of African American women with uterine cancer. Methods Literature on disparities in uterine cancer was systematically reviewed using the PubMed search engine. Articles from 1992-2012 written in English were reviewed. Search terms included endometrial cancer, uterine cancer, racial disparities, and African American. Results Twenty-four original research articles with a total of 366,299 cases of endometrial cancer (337,597 Caucasian and 28,702 African American) were included. Compared to Caucasian women, African American women comprise 7% of new endometrial cancer cases, while accounting for approximately 14% of endometrial cancer deaths. They are diagnosed with later stage, higher-grade disease, and poorer prognostic histologic types compared to their Caucasian counterparts. They also suffer worse outcomes at every stage, grade, and for every histologic type. The cause of increased mortality is multifactorial. African American and white women have varying incidence of comorbid conditions, genetic susceptibility to malignancy, access to care and health coverage, and socioeconomic status; however, the most consistent contributors to incidence and mortality disparities are histology and socioeconomics. More robust genetic and molecular profile studies are in development to further explain histologic differences. Conclusions Current studies suggest that histologic and socioeconomic factors explain much of the disparity in endometrial cancer incidence and mortality between white and African American patients. Treatment factors likely contributed historically to differences in mortality; however, studies suggest most women now receive equal care. Molecular differences may be an important factor to explain the racial inequities. Coupled with a sustained commitment to increasing access to appropriate care, on-going research in biologic mechanisms underlying histopathologic differences will help address and reduce the number of African American women who disproportionately suffer and die from endometrial malignancy.

show abstract

“…Also of note are the existence of racial disparities in uterine cancers that persist between blacks and whites, even with equal access to health care in the DOD health system [28]. The findings from this research appear to suggest the existence of widening health disparities, especially among veterans from various racial/ethnic groups.…”

Section: Introductionmentioning

confidence: 67%

The Military Health Care System May Have the Potential to Prevent Health Care Disparities

Pierre-Louis¹,

Moore

Hamilton

2014

J. Racial and Ethnic Health Disparities

View full text Add to dashboard Cite

show abstract

Racial disparities in histopathologic characteristics of uterine cancer are present in older, not younger blacks in an equal-access environment

Cited by 46 publications

References 41 publications

Gynecologic cancer disparities: A report from the Health Disparities Taskforce of the Society of Gynecologic Oncology

Gynecologic cancer disparities: A report from the Health Disparities Taskforce of the Society of Gynecologic Oncology

Disparities in uterine cancer epidemiology, treatment, and survival among African Americans in the United States

The Military Health Care System May Have the Potential to Prevent Health Care Disparities

Contact Info

Product

Resources

About