Racial disparity in the utilization of multiparametric MRI–ultrasound fusion biopsy for the detection of prostate cancer

Hoge, Connor; Verma, Sadhna; Lama, Daniel; Bergelson, Ilana; Haj-Hamed, Monzer; Maynor, Sean; Gaitonde, Krishnanath; Sidana, Abhinav

doi:10.1038/s41391-020-0223-5

Cited by 28 publications

(15 citation statements)

References 35 publications

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“…The continual development and increased utilization of FBx has led to a shift in the way PCa is diagnosed. Many studies have shown that the utility of FBx is in the combination of SBx and MRI-targeted cores, [3][4][5][6][7][8] although some studies argue that MRI-targeted cores alone would significantly reduce insignificant cancer diagnosis. 9 In contrast to the multitude of studies on the possible efficacy of MRItargeted biopsy alone in FBx, to our knowledge, there has not been a study that looked solely at utilization of the machineguided SBx of an FBx captured by a software-assisted (fusion) registration device.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Cancer Detection Rates Between Template Systematic Biopsies Obtained Using Magnetic Resonance Imaging-Ultrasound Fusion Machine and Freehand Transrectal Ultrasound-Guided Systematic Biopsies

Hoge

Maynor

Guan

et al. 2020

Journal of Endourology

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Introduction: There are reports that the 12-core template systematic biopsies (SBx) obtained by using software registration machines (e.g., Artemis) have higher cancer detection rates (CDRs) of prostate cancer (PCa) than the standard, freehand 12-core transrectal ultrasound (TRUS)-guided biopsies. The goal of our study is to compare the clinically significant (CS) CDRs of SBx in two independent cohorts who underwent freehand TRUS-SBx alone (Cohort A) or machine-guided SBx as part of a combined MRI-ultrasound (MRI-US) fusion biopsy (FBx) (Cohort B). Materials and Methods: A retrospective review of all patients undergoing prostate biopsies over a 4-year period at the University of Cincinnati Medical Center was performed. CS cancer was defined as having a Gleason score ‡7. MRI-US FBx were obtained by using an Artemis software registration device (ARTEMISÔ, Eigen, Inc., Grass Valley, CA). Statistical significance was considered at p < 0.05. Results: Nine hundred and thirty men underwent SBx (Cohort A: 474, Cohort B: 456). There were no statistical differences between cohort A and B in CS CDRs in the overall population (39.3% vs 33.8%; p = 0.093), biopsy naive patients (40.4% vs 39.8%; p = 0.951), or patients with a prior negative biopsy (22.7% vs 25.0%; p = 0.910). Multivariate logistic regression controlling for age, race, prostate-specific antigen level, prostate volume, abnormal digital rectal exam, and family history of PCa demonstrated comparable CS CDRs, which was maintained when further stratified by prior biopsy history (all patients: odds ratio [OR] 0.99, 95% confidence interval [CI] 0.71-1.38, p = 0.958; biopsy naive: OR 0.79, 95% CI 0.51-1.22, p = 0.291; prior negative biopsy: OR 0.64, 95% CI 0.21-1.75, p = 0.403). Conclusions: Our study did not find a significant difference in the CS CDRs of machine-guided SBx compared with the freehand TRUS-SBx. Unless the SBx is done at the time of FBx, the use of these machines for obtaining SBx only is unlikely to result in any increase of CS CDRs.

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Section: Discussionmentioning

confidence: 99%

A Comparison of Cancer Detection Rates Between Template Systematic Biopsies Obtained Using Magnetic Resonance Imaging-Ultrasound Fusion Machine and Freehand Transrectal Ultrasound-Guided Systematic Biopsies

Hoge

Maynor

Guan

et al. 2020

Journal of Endourology

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“…Multiparametric magnetic resonance imaging–ultrasound fusion biopsy is increasingly being used for the evaluation of men with clinical suspicion of PCa because it has been found to increase the detection of clinically significant cancer while decreasing the detection of clinically insignificant cancer compared with the standard 12‐core systematic biopsy 5 . Our recently published analysis found that biopsy‐naive AA men were significantly less likely to receive multiparametric magnetic resonance imaging–ultrasound fusion biopsy compared with white men, thereby providing some evidence of the true depth at which the racial disparities in PCa exist, even extending to how it initially is diagnosed 6 …”

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confidence: 86%

Equal access to health care reduces racial disparities in prostate cancer outcomes

Hoge

Sussman

Sidana

2020

Cancer

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“…Older adults are also more likely to move more while in the scanner, affecting scan quality [5]. Furthermore, the need for medical personnel and settings (i.e., hospital) disproportionately discourages underrepresented minorities from participating in clinical trials and biomedical research [6,7] and seeking diagnoses or treatment [8]. Thus, a low-cost, non-invasive, and widely-accessible method to identify hippocampal atrophy in older adults is needed.…”

Section: Introductionmentioning

confidence: 99%

Association between motor task acquisition and hippocampal atrophy across cognitively unimpaired, amnestic Mild Cognitive Impairment, and Alzheimer’s disease individuals

Sy¹,

Malek-Ahmadi

Hooyman³

et al. 2021

Preprint

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Hippocampal atrophy is a widely used biomarker for Alzheimer's disease (AD), but the cost, time, and contraindications associated with magnetic resonance imaging (MRI) limit its use. Recent work has shown that a low-cost upper extremity motor task has potential in identifying AD risk. Fifty-four older adults (15 cognitively unimpaired, 24 amnestic Mild Cognitive Impairment, and 15 AD) completed six motor task trials and a structural MRI. Motor task acquisition significantly predicted bilateral hippocampal volume, controlling for age, sex, education, and memory. Thus, this motor task may be an affordable, non-invasive screen for AD risk and progression.

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Racial disparity in the utilization of multiparametric MRI–ultrasound fusion biopsy for the detection of prostate cancer

Cited by 28 publications

References 35 publications

A Comparison of Cancer Detection Rates Between Template Systematic Biopsies Obtained Using Magnetic Resonance Imaging-Ultrasound Fusion Machine and Freehand Transrectal Ultrasound-Guided Systematic Biopsies

A Comparison of Cancer Detection Rates Between Template Systematic Biopsies Obtained Using Magnetic Resonance Imaging-Ultrasound Fusion Machine and Freehand Transrectal Ultrasound-Guided Systematic Biopsies

Equal access to health care reduces racial disparities in prostate cancer outcomes

Association between motor task acquisition and hippocampal atrophy across cognitively unimpaired, amnestic Mild Cognitive Impairment, and Alzheimer’s disease individuals

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