Racial Disproportionality in Covid Clinical Trials

Chastain, Daniel B; Osae, Sharmon P.; Henao‐Martínez, Andrés F.; Franco‐Paredes, Carlos; Chastain, Joeanna S.; Young, Henry N.

doi:10.1056/nejmp2021971

Cited by 149 publications

(142 citation statements)

References 5 publications

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“…Multiple studies have highlighted a number of other reasons as to why trials tend to disadvantage minorities from attending. This includes; poor health literacy, hidden costs related to reaching trials, lack of knowledge about the condition being studied, distrust in the research process and the researchers, and language barriers [8], [23].…”

Section: Discussionmentioning

confidence: 99%

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The UPTAKE study: Implications for the future of COVID-19 vaccination trial recruitment in UK and beyond

Sethi

Kumar

Mandal

et al. 2021

Preprint

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Background: Developing a safe and effective vaccine will be the principal way of controlling the COVID-19 pandemic. However, current COVID-19 vaccination trials are not adequately representing a diverse participant population in terms of age, ethnicity and comorbidities. Achieving the representative recruitment targets that are adequately powered to the study remains one of the greatest challenges in clinical trial management. To ensure accuracy and generalizability of the safety and efficacy conclusions generated by clinical trials, it is crucial to recruit patient cohorts as representative as possible of the future target population. Missing these targets can lead to reduced validity of the study results, and can often slow down drug development leading to costly delays. This study explores the key factors related to perceptions and participation in vaccination trials. Methods: This study involved an anonymous cross-sectional online survey circulated across the UK. Statistical analysis was done in six phases. Multi-nominal logistic models examined demographic and geographic factors that may impact vaccine uptake. Results: The survey had 4884 participants of which 9·44% were BAME (Black Asian Minority Ethnic). Overall 2020 (41.4%) respondents were interested in participating in vaccine trials; 27.6% of the respondents were not interested and 31.1.% were unsure. The most interested groups were male (OR=1.290), graduates (OR=1.277), the 40-49 and 50-59 age group (OR=1.880 and OR=1.460 respectively) and those with no health issues (OR=1.064). The least interested groups were BAME (OR=0.427), those from villages and small towns (OR=0.66 and 0.54 respectively), and those aged 70 and above (OR=1.11).Conclusions: In order to have a vaccination that is generalizable to the entire population, greater work needs to be done in engaging a diverse cohort of participants. Public health campaigns need to be targeted in improving trial recruitment rates for the elderly, BAME community and the less educated rural population.

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Section: Discussionmentioning

confidence: 99%

“…Having greater diversity in principal investigators can be bene cial with this. This may curtail bias in recruitment of participants from underrepresented populations and allow for improved communication during recruitment [17], [20], [23].…”

Section: Tackling Barriers Towards Trial Recruitmentmentioning

confidence: 99%

The UPTAKE study: Implications for the future of COVID-19 vaccination trial recruitment in UK and beyond

Sethi

Kumar

Mandal

et al. 2021

Preprint

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show abstract

“…The communities of racial minorities, both black and Hispanic, have been disproportionately affected by COVID-19 [11][12][13][14][15] from the early stages of the pandemic. A recent study [16] of 1000 children tested for SARS-CoV-2 showed that minority children have a higher odds of testing positive with non-Hispanic blacks having an adjusted odds of infection of 2.3 and Hispanics having an adjusted odds of infection of 6.3 over non-Hispanic whites.…”

Section: Introductionmentioning

confidence: 99%

Socio-Economic Disparities and COVID-19 in the USA

Paul¹,

Englert

Varga

2020

SSRN Journal

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COVID-19 is not a universal killer. We study the spread of COVID-19 at the county level for the United States up until the 15 th of August, 2020. We show that the prevalence of the disease and the death rate are correlated with the local socioeconomic conditions often going beyond local population density distributions, especially in rural areas. We correlate the COVID-19 prevalence and death rate with data from the US Census Bureau and point out how the spreading patterns of the disease show asymmetries in urban and rural areas separately and is preferentially affecting the counties where a large fraction of the population is non-white. Our findings can be used for more targeted policy building and deployment of resources for future occurrence of a pandemic due to SARS-CoV-2. Our methodology, based on interpretable machine learning and game theory, can be extended to study the spread of other diseases.

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“…Firstly, many people have legitimate concerns around the safety and efficacy of COVID-19 vaccines due to factors including the speed of their development, the underrepresentation of ethnic minority groups in clinical trials 10 and the unknown longevity of their immunological effects. The public must feel freely able to voice these concerns, raise challenging questions and expect transparent replies from trusted institutions.…”

mentioning

confidence: 99%

Online ‘anti-vax’ campaigns and COVID-19: censorship is not the solution

Armitage

2021

Public Health

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Racial Disproportionality in Covid Clinical Trials

Cited by 149 publications

References 5 publications

The UPTAKE study: Implications for the future of COVID-19 vaccination trial recruitment in UK and beyond

The UPTAKE study: Implications for the future of COVID-19 vaccination trial recruitment in UK and beyond

Socio-Economic Disparities and COVID-19 in the USA

Online ‘anti-vax’ campaigns and COVID-19: censorship is not the solution

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Racial Disproportionality in Covid Clinical Trials

Cited by 149 publications

References 5 publications

The UPTAKE study: Implications for the future of&nbsp;COVID-19 vaccination trial recruitment in&nbsp;UK and beyond

The UPTAKE study: Implications for the future of&nbsp;COVID-19 vaccination trial recruitment in&nbsp;UK and beyond

Socio-Economic Disparities and COVID-19 in the USA

Online ‘anti-vax’ campaigns and COVID-19: censorship is not the solution

Contact Info

Product

Resources

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The UPTAKE study: Implications for the future of COVID-19 vaccination trial recruitment in UK and beyond

The UPTAKE study: Implications for the future of COVID-19 vaccination trial recruitment in UK and beyond