Aerodynamic drag is the main resistive force in cycling at high speeds and on flat terrain, so reducing it is critical to improve cyclist performance. Aerodynamic comparisons have been made in the past between different types of wheels, and disc wheels were often the best performers. However, to the best of our knowledge, there are no studies in the available literature on how modifications to the disc wheel geometry can improve its performance. Therefore, this paper studies and compares the aerodynamics of disc wheels with flat side discs and with curved side discs (lenticular). Moreover, semi-lenticular front wheels with an asymmetrical shape are introduced. All but one of the simulated (semi )lenticular wheels perform better than the flat disc wheels at all yaw angles, e.g., the maximum CD reduction was 5.5%, 10.9% and 87.5% at 0°, 4° and 8° yaw angle, respectively. Semi-lenticular wheels provide a lower CD at medium and large yaw angles compared to corresponding symmetric lenticular wheels. Moreover, the large influence of the ratio of tire width to wheel width on the aerodynamic drag of cycling wheels is confirmed. These results will help riders in their wheels choice and will help manufacturers to design future disc wheels.