RAD-140 Drug-Induced Liver Injury

Leung, Kenneth; Yaramada, Priyanka; Goyal, Preeya; Cai, Cindy X.; Thung, Irene; Hammami, Muhammad B.

doi:10.31486/toj.22.0005

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…In three of the four case studies, male patients ranging from 24 to 52 years old who supplemented RAD140 for 4-5 months developed significant drug-induced liver damage measured by canalicular cholestasis, prominent ductular reaction and mild lobular inflammation. [55][56][57] In the fourth case study, a 32-year-old man who had recently begun supplementing RAD140 (duration unknown) experienced muscle membrane damage, assessed by blood markers of creatinine kinase, c-reactive protein, troponin I, and B-type natriuretic peptide. A computed tomography angiogram further revealed significant acute myocarditis and congestive heart failure.…”

Section: Young Controlmentioning

confidence: 99%

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice

Brown,

Ganjayi,

Baumann

2023

Clin Exp Pharma Physio

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RAD140 is a selective androgen receptor modulator that produces anabolic effects within skeletal muscle. Thus, RAD140 may be effective at treating sarcopenia. No long‐term studies have investigated how RAD140 influences strength in ageing muscle. This study aimed to determine how 10 weeks of RAD140 supplementation impacts strength, recovery from exercise, and overall health in ageing mice. Young and adult females were assigned to receive RAD140 (5 mg/kg) or a control solution. Dorsiflexor muscles were exposed to repeated bouts of eccentric contractions, and torque was measured before and after each bout. Adaptive potential and strength gains were calculated to assess the efficacy of RAD140 in muscle, while frailty status and mortality risk were used to measure health span. Supplementation of RAD140 increased frailty status and mortality risk in the young and adult treated groups compared to the controls (p ≤ 0.042). RAD140 decreased adaptive potential in young (p = 0.040) but not adult mice (p = 0.688). Torque did not differ between groups after 2–3 weeks of recovery (p ≥ 0.135). In conclusion, long‐term RAD140 supplementation reduced indices of overall health and failed to improve strength in female mice, suggesting that RAD140 (at a 5mg/kg dosage) may be more detrimental than beneficial in delaying or preventing sarcopenia.

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Section: Young Controlmentioning

confidence: 99%

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice

Brown,

Ganjayi,

Baumann

2023

Clin Exp Pharma Physio

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Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport

Bohlin,

Pohanka,

Andersson

et al. 2023

Drug Testing and Analysis

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Selective androgen receptor modulators (SARMs) are prohibited by the World Anti‐Doping Agency (WADA) since 2008. Similarly, to anabolic androgenic steroids (AAS), SARMs are detrimental to health not only in athletes but also in the general population. However, studies of the occurrence of SARMs outside of sport are scarce. Swedish healthcare samples from the Drugs of Abuse Laboratory at Karolinska were analyzed using WADA‐accredited screening methods at the Doping Control Laboratory in Stockholm to estimate the frequency of SARM use outside of the WADA laboratories. Twenty (4%) of the male urine samples (n = 542) were positive for SARMs, whereas none of the analyzed female samples (n = 100) contained any SARMs. The top three SARMs found were LGD‐4033 followed by RAD140 and ostarine. Two or more SARMs were found in >50% of the SARM‐positive samples. AASs were identified in 40% of samples containing SARMs. A difference between genders was observed where 34% male and 7% female samples contained AAS. Many samples displayed testosterone/epitestosterone values indicative of testosterone intake, without presence of other AAS, and hence, there is a risk that these samples are being falsely reported as negative. Our results indicate that SARM use might be a concern outside of sport. Subsequently, in addition to AAS, the healthcare system should also be informed about SARM abuse and the associated adverse side effects.

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Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases

Leciejewska,

Jędrejko,

Gómez-Renaud

et al. 2023

Eur J Clin Pharmacol

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Purpose Selective androgen receptor modulators (SARMs) have demonstrated agonist activity on the androgen receptor in various tissues, stimulating muscle mass growth and improving bone reconstruction. Despite being in clinical trials, none has been approved by the Food and Drug Administration (FDA) or European Medicines Agency for pharmacotherapy. Still, SARMs are very popular as performance-enhancing drugs. The FDA has issued warnings about the health risks associated with SARMs, but the long-term exposure and possible adverse events still need to be fully understood. This review aims to evaluate the adverse events associated with using SARMs by humans. Methods PubMed database was searched from September 16, 2022, to October 2, 2023. In total, 20 records were included in the final review. Data from preclinical and clinical studies supported the review. Results Since 2020, 20 reports of adverse events, most described as drug-induced liver injury associated with the use of SARM agonists, have been published. The main symptoms mentioned were cholestatic or hepatocellular liver injury and jaundice. Limited data are related to the dosages and purity of SARM supplements. Conclusion Promoting SARMs as an anabolic agent in combination with other performance-enhancing drugs poses a risk to users not only due to doping controls but also to health safety. The lack of quality control of consumed supplements makes it very difficult to assess the direct impact of SARMs on the liver and their potential hepatotoxic effects. Therefore, more detailed analyses are needed to determine the safety of using SARMs.

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RAD-140 Drug-Induced Liver Injury

Cited by 8 publications

References 15 publications

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice

Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport

Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases

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