RAD21 overexpression is frequently observed in BRCA-X Prostate Cancers

Deb, S; Huiling, X; Thorne, Heather; Willems-Jones, A; Clouston, David; Bolton, Damien; Ramsay, Robert G.; Fox, SB

doi:10.1186/1897-4287-10-s2-a59

Cited by 3 publications

(2 citation statements)

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“…There are a number of interactions linking RAD21 to BRCA2, the most strongly associated prostate cancer pre-disposition gene [47]. RAD21 over-expression is commonly observed in BRCA2 present prostate cancer [55], where RAD21 is a key component of a cohesion complex needed for several cellular processes. In fact, RAD21 over-expression was present in 53% of the prostate tumours and is perhaps an equivalently useful biomarker in prostate cancer as BRCA2.…”

Section: Resultsmentioning

confidence: 99%

Prostate Cancer Gene Regulatory Network Inferred from RNA-Seq Data

Moore

Simoes

Dehmer

et al. 2019

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Background: Cancer is a complex disease with a lucid etiology and in understanding the causation, we need to appreciate this complexity. Objective: Here we are aiming to gain insights into the genetic associations of prostate cancer through a network-based systems approach using the BC3Net algorithm. Methods: Specifically, we infer a prostate cancer Gene Regulatory Network (GRN) from a large-scale gene expression data set of 333 patient RNA-seq profiles obtained from The Cancer Genome Atlas (TCGA) database. Results: We analyze the functional components of the inferred network by extracting subnetworks based on biological process information and interpret the role of known cancer genes within each process. Furthermore, we investigate the local landscape of prostate cancer genes and discuss pathological associations that may be relevant in the development of new targeted cancer therapies. Conclusion: Our network-based analysis provides a practical systems biology approach to reveal the collective gene-interactions of prostate cancer. This allows a close interpretation of biological activity in terms of the hallmarks of cancer.

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Section: Resultsmentioning

confidence: 99%

Prostate Cancer Gene Regulatory Network Inferred from RNA-Seq Data

Moore

Simoes

Dehmer

et al. 2019

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“…Mutated RAD21 has been detected in 2.48% of all cancers and represents adenocarcinomas of the breast, lung, colon, and prostate [ 14 ]. Furthermore, RAD21 overexpression is associated with more aggressive PCa and is frequently observed in BRCA-mutated prostatic tumors [ 29 ]. In addition, RAD21 is commonly amplified in advanced androgen-resistant PCa [ 30 ], suggesting alternative genetic mechanisms in our patient.…”

Section: Discussionmentioning

confidence: 99%

Ductal Adenocarcinoma of the Prostate with Novel Genetic Alterations Characterized by Next-Generation Sequencing

Zara Rozalen,

Martin,

Rajendran

et al. 2024

Current Oncology

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Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic characteristics are still evolving, prompting the suggestion that all DAP would benefit from molecular analysis with the purpose of improving tumor recognition, genetic classification, and, ultimately, personalized therapy. Herein, we report a case of DAP with novel genetic alterations (BCOR P1153S, ERG M219I, KDR A750E, POLE S1896P, and RAD21 T461del).

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Whole-transcriptome analysis of hepatocellular carcinoma

et al. 2013

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Hepatocellular carcinoma (HCC) is one of the leading causes of death in the world. It involves a complicated pathogenesis. In the present study, we tried to uncover the underlying mechanisms from the RNA level. Whole-transcriptome analysis using RNA-seq data showed that the tumor cells had higher expression levels of genes compared to normal tissue cells, with much more genes related to metabolism, synthesis, and transportation. A total of 4,638 differentially expressed genes were obtained in HCC, in which 3,476 were up-regulated and 1,162 were down-regulated. A total of 2,367 new isoforms and 46 fusion genes were detected in HCC cells using computational method. Within these variants, new isoforms of NIR and fusion genes PARP15-AHSG caught our attention for their potential roles in cancer development. These findings could be beneficial in guiding future researches.

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RAD21 overexpression is frequently observed in BRCA-X Prostate Cancers

Cited by 3 publications

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Prostate Cancer Gene Regulatory Network Inferred from RNA-Seq Data

Prostate Cancer Gene Regulatory Network Inferred from RNA-Seq Data

Ductal Adenocarcinoma of the Prostate with Novel Genetic Alterations Characterized by Next-Generation Sequencing

Whole-transcriptome analysis of hepatocellular carcinoma

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