Radar plots: A novel modality for displaying disparate data on the efficacy of eluxadoline for the treatment of irritable bowel syndrome with diarrhea

Brenner, Darren M.; Dove, Leonard S.; Andrae, David; Covington, Paul S.; Gutman, Catherine R.; Chey, William D.

doi:10.1111/nmo.13331

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Furthermore, eluxadoline also improves a constellation of symptoms associated with IBS-D 106 . In the Phase 3 trials, patients receiving eluxadoline achieved reductions in fecal urgency, bloating, and daily number of bowel movements compared to those receiving placebo, with significantly higher proportions achieving improved stool consistency (BSFS score <5 or no bowel movement on !50% of treatment days) and adequate relief of symptoms (Figure 2) 71,106 . A significantly higher proportion of patients treated with eluxadoline 100 mg achieved !40% (p¼.008) or !50% (p¼.009) reduction in their worst abdominal pain compared to placebo (not significant for !30% improvement) 71 .…”

Section: Efficacymentioning

confidence: 97%

“…There is a high prevalence of IBS-D in the US, and while the condition is not life-threatening or associated with major complications, it can prove debilitating for patients, with significant associated costs 4,10,16,17 . Therefore, while the possibility of serious side effects with eluxadoline must be balanced against the non-fatal nature of the disease and the risk factors of each patient, eluxadoline represents a viable treatment option for patients with IBS-D, given its efficacy in alleviating a range of abdominal and bowel symptoms 106 .…”

Section: Contraindicationsmentioning

confidence: 99%

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Management of irritable bowel syndrome with diarrhea: focus on eluxadoline

Jones¹,

Lembo

Heidelbaugh

et al. 2021

Current Medical Research and Opinion

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Objective: We sought to summarize current recommendations for the diagnosis of diarrhea-predominant irritable bowel syndrome (IBS-D) and describe available management options, highlighting a newer US Food and Drug Administration (FDA)-approved agent, eluxadoline. Methods: Literature on IBS-D was assessed up to January 2020 using PubMed, with key search terms including "IBS-D diagnosis", "IBS-D management", and "eluxadoline". Results: IBS is a common gastrointestinal disorder affecting up to 14% of US adults and is particularly prevalent in women and those aged under 50. Symptoms include abdominal pain associated with altered bowel habits (i.e. diarrhea and/or constipation subtyped based on the predominant stool pattern). As IBS-D is challenging to manage with varying symptom severity, effective treatment requires a personalized management approach. Evidence-based therapeutic options endorsed by the American Gastroenterological Association and the American College of Gastroenterology can be used to effectively guide treatment. Dietary and lifestyle modifications, including adequate hydration, reducing caffeine and alcohol intake, and increasing soluble fiber intake may lead to symptom improvement. Over-the-counter medications such as loperamide are frequently recommended and may improve stool frequency and rectal urgency; however, for the outcome of abdominal pain, mixed results have been observed. Several off-label prescription medications are useful in IBS-D management, including tricyclic antidepressants, bile acid sequestrants, and antispasmodics. Three prescription medications have been approved by the FDA for IBS-D: alosetron, eluxadoline, and rifaximin. Conclusions: IBS-D can be effectively managed in the primary care setting in the absence of alarm features. Benefits and risks of pharmacologic interventions should be weighed during treatment selection.

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Section: Efficacymentioning

confidence: 97%

Section: Contraindicationsmentioning

confidence: 99%

Management of irritable bowel syndrome with diarrhea: focus on eluxadoline

Jones¹,

Lembo

Heidelbaugh

et al. 2021

Current Medical Research and Opinion

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“…26 In the field of sport, as in others, one of the graphs that has been used recently is the radar plot. [27][28][29][30][31] The radar plot: What is it and what information does it provide?…”

Section: Use Of Graphical Visualizationsmentioning

confidence: 99%

“…In the field of sport, as in others, one of the graphs that has been used recently is the radar plot. 27–31…”

Section: Use Of Graphical Visualizationsmentioning

confidence: 99%

Violinboxplot and enhanced radar plot as components of effective graphical dashboards: An educational example of sports analytics

Casals

Daunis‐i‐Estadella

2022

International Journal of Sports Science & Coaching

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A statistical graph can offer an alternative compelling approach to statistical thinking that focuses on important concepts rather than procedural formulas. Nowadays, visualizing multidimensional/multivariate data is essential but can also be challenging. In sport analytics, the exploration and descriptive analysis of data using visualization techniques has increased in recent years to, for example, describe possible patterns and uncertainty of player performance. These visualization techniques have been used so far with different purposes by various professionals in the sport industry, such as managers, coaches, scouters, technical staff, journalists, and researchers. The abuse of graphs, such as the radar plot, and their frequent misinterpretation in the world of sports and possible implications for coaching decisions has led us to create more informative and accurate visualizations. Here, we propose new, more educational visualizations we have termed violinboxplots and enhanced radar plot for their use in the sports analytics and other fields. These allow us to visualize, besides distribution and statistical summaries, the extreme data values that can be fundamental in performance studies and allow us to benchmark.

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Heat stress tolerance in wheat seedling: Clustering genotypes and identifying key traits using multivariate analysis

Hasan,

Mia,

Ahmed

et al. 2024

Heliyon

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Radar plots: A novel modality for displaying disparate data on the efficacy of eluxadoline for the treatment of irritable bowel syndrome with diarrhea

Abstract: Data presentation in radar plot format facilitates interpretation across multiple domains, demonstrating that eluxadoline treatment led to improvements vs placebo across 13 endpoints representing the range of symptoms experienced by patients with IBS-D.

Cited by 4 publications

References 25 publications

Management of irritable bowel syndrome with diarrhea: focus on eluxadoline

Management of irritable bowel syndrome with diarrhea: focus on eluxadoline

Violinboxplot and enhanced radar plot as components of effective graphical dashboards: An educational example of sports analytics

Heat stress tolerance in wheat seedling: Clustering genotypes and identifying key traits using multivariate analysis

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