Pickering (1932) showed that the increase in hand blood flow, which occurs when the opposite forearm and hand are immersed in warm water, is prevented if the flow of blood in the veins of the heated arm is arrested. This implies that one component in the initiation of hand vasodilatation is the activation of centrally placed receptors by a rise in blood temperature. Benzinger (1962) concluded that the activity of heat-loss mechanisms is principally dependent upon a central receptor mechanism. There is, however, evidence that this is not the only mechanism involved in vasodilatation due to warming. When radiant heat is applied to the trunk, vasodilatation may begin in the hand within as little as 15 sec, and may proceed in spite of a falling central temperature (Kerslake & Cooper, 1950; Cooper & Kerslake, 1954). These observations imply that there is also a reflex component in the initiation of vasodilatation.Reflex vasodilatation in the hand is used clinically as a test of the integrity of the autonomic nervous system. It is therefore necessary to know the circumstances in which this reflex can be expected to occur. The present investigations are concerned with the influence of central temperature and of trunk skin temperature on this reflex.
METHODSTo study effect of central temperature Material. Twenty-seven subjects (sixteen male, eleven female) aged 17-86 yr were examined. They were patients admitted to hospital with various disorders and none had a known disorder of temperature regulation. Subject M.M., a man aged 17 yr, had received a severe head injury 14 months previously and was unconscious. Sweating in response to radiant heat was slightly greater on the right than the left side of the body but vasomotor reflexes, namely the response of the arterial blood pressure to Valsalva's manoeuvre, to change of posture and to noise were within the normal range. Subject G.W., male, aged 34 yr, had had poliomyelitis 2k yr before and was paralysed below the neck except that he was capable of slight movement of the right toes. He was dependent upon artificial