Radial Bending Breaking Resistance Derived by Densitometric Evaluation Predicts Femoral Neck Fracture

Gatti, Davide; Sartori, Eleonora; Braga, V.; Corallo, Fabio; Rossini, Maurizio; Adami, Silvano

doi:10.1007/s001980170038

Cited by 23 publications

(19 citation statements)

References 17 publications

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“…Bone structural properties were analyzed before and after adjustment for body mass. Bone mineral density and bone size are related to total body mass, and bone mineral density influences bone strength (25). Therefore, structural properties were reported without and with adjustment for body mass (26).…”

Section: Resultsmentioning

confidence: 99%

Dietary Restriction Does Not Adversely Affect Bone Geometry and Mechanics in Rapidly Growing Male Wistar Rats

et al. 2005

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The present study assessed the effects of dietary restriction on tibial and vertebral mechanical and geometrical properties in 2-mo-old male Wistar rats. Two-month-old male Wistar rats were randomized to the ad libitum (n ϭ 8) or the 35% dietrestricted (DR) feeding group (n ϭ 9) for 5 mo. Tibiae and L 6 vertebrae were dissected out for microcomputed tomography (CT) scanning and subsequently fractured in biomechanical testing to determine geometrical and mechanical properties. The DR group had significantly lower mean tibial length, mass, area, and cross-sectional moment of inertia, as well as vertebral energy to maximal load. After adjustment for body mass, however, DR tibial mean maximal load and stiffness, and DR vertebral area, height, volume, and maximal load were significantly greater, relative to ad libitum means. No significant differences were found between the DR and ad libitum mineral ash fractions. Because the material properties of the tibiae between the two groups were not significantly different, presumably the material integrity of the bones was not adversely affected as a consequence of DR. The similar material characteristics were consistent with mineral ash fractions that were not different between the two groups. Vertebral maximal load and stiffness were not significant between the DR and ad libitum animals. Importantly, we show that a level of dietary restriction (35%) that is less severe than many studies (40%), and without micronutrient compensation does not adversely affect tibial and vertebral mechanical properties in young growing male rats when normalized for body mass. th lumbar CT, microcomputed tomography DR has emerged as an important avenue of investigation in the area of aging-specifically the prevention of aging. DR can increase both mean and maximal life span in a variety of animals, including rodents and primates (1). Whereas some studies of DR have focused singularly on reducing total calories, without compensation for micronutrient intake (2-4), others have maintained adequate and equal vitamin and mineral status for both DR and ad libitum animals (5,6). Studyto-study variations exist in method and degree of restriction, period of dietary restriction, and the age at onset of restriction, and contribute to the lack of consensus on the effects of dietary restriction on bone adaptation.Talbott et al. (7) used "younger" (3-mo-old) and "older" (10-mo-old) female Sprague-Dawley rats, matched for body mass and assigned to one of four diet groups representing two levels of energy (referred to as "caloric") intake and two levels of calcium intake. All rats had the same baseline diet (protein, fat, fiber, vitamins, and other minerals), but differed in caloric intake (normal versus 40% restriction) by reduced carbohydrate content or levels of calcium intake (normal ϭ 78 mg/d and low ϭ 15 mg/d). Rats were, therefore, restricted in calcium only, calories only, or calcium and calories, for a period of 9 wk. Dietary restriction of calcium or energy resulted in an elevated rate of bone turno...

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Section: Resultsmentioning

confidence: 99%

Dietary Restriction Does Not Adversely Affect Bone Geometry and Mechanics in Rapidly Growing Male Wistar Rats

et al. 2005

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“…(5) The occurrence of periosteal apposition with aging in men and women had been suggested by previous cross-sectional studies. (4,10,18,19) However, this is the first longitudinal evidence to show that cross-sectional data cannot capture the heterogeneity of changes in bone parameters over the life span and how they differ between men and women.…”

Section: Figmentioning

confidence: 89%

“…However, the rate of endocortical reabsorption in women is much higher than in men and considerably exceeds the effect of periosteal apposition. The cross-sectional moment of inertia-a derived parameter that summarizes how parallel changes in bone material and in bone geometry translate into changes in bone mechanical properties (bone mechanical resistance to bending) (10) -declined over the life span in both sexes. An overall model of change in bone macroarchitecture over the aging process is given in Fig.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Changes in BMD and Bone Geometry in a Population-Based Study

Lauretani

Bandinelli

Griswold³

et al. 2008

Journal of Bone and Mineral Research

116

119

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We prospectively examined vBMD and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6-yr follow-up. Periosteal apposition occurred both in men and women. Endocortical resorption causes bone loss in older women despite periosteal apposition.Introduction: To address the hypothesis that age-related changes in BMD and bone geometry may be different in men and women, we prospectively examined volumetric BMD (vBMD) and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6-yr follow-up. Materials and Methods: Three hundred forty-five men and 464 women 21-102 yr of age from the InCHIANTI study, a population-based study in Tuscany, Italy, were included. Tibial QCT bone parameters were measured at enrollment (1998)(1999)(2000) and at 3-(2001-2003) and 6-yr (2004-2006) follow-ups. Results: Periosteal apposition occurred both in men and women. The annual rate of bone periosteal apposition was higher in younger than in older men, whereas in women, the rate of apposition was homogenous across age groups. The age-related medullary expansion, expression of endocortical resorption, was significantly higher in women compared with men. In women, but not in men, accelerated endocortical resorption not sufficiently balanced by periosteal apposition caused accelerated loss in cortical bone mass. The cross-sectional moment of inertia decreased progressively over the life span in both sexes. Conclusions: Endocortical resorption causes bone loss in older women despite periosteal apposition. Obtaining a balance between endocortical resorption and periosteal apposition should be the target for interventions aimed to decrease bone loss and prevent osteoporosis in older women.

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“…DXA evaluations at the hip and vertebral lateral projections were excluded from the statistical analysis since appropriate measurements in these sites could not be obtained in 20% of the patients, mainly due to problems in obtaining correct positioning. Bone mineral content (BMC) and BMD at the forearm were measured by the Osteoplan system (NIM, Verona, Italy) as reported previously (39). The CV for duplicate measurements were fewer than 1.7% in normal children.…”

Section: Clinical and Laboratory Studiesmentioning

confidence: 99%

GH in combination with bisphosphonate treatment in osteogenesis imperfecta

Antoniazzi

Monti²,

Venturi³

et al. 2010

European Journal of Endocrinology

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Objective: To verify the effects of bisphosphonates (Bps) in combination with recombinant human GH (rGH) in pediatric osteogenesis imperfecta (OI) patients; we focused on possible improvement of bone mineral density (BMD), projected bone areas, growth velocity, and fractures risk. Design: A randomized controlled 1-year clinical trial on 30 prepubertal children (M:FZ14:16) affected by OI (type I, IV, and III) being treated with neridronate. Methods: Following an observational period of 12 months during ongoing neridronate treatment, the patients were randomly divided into two groups: 15 were treated for 12 months with rGH and neridronate (group BpCrGH) and 15 continued neridronate alone (group Bp). We evaluated auxological parameters, number of fractures, bone age (BA), bone metabolic parameters, and bone mass measurements (at lumbar spine and radius by dual-energy X-ray absorptiometry). Results: The mean variation in percentage of BMD (D%BMD) -at lumbar spine (L2-L4), at distal and ultradistal radius -and the projected area of lumbar spine increased significantly in group BpCrGH (P!0.05). Growth velocity was significantly higher during rGH treatment in group BpCrGH versus group Bp and versus pretreatment (P!0.05), with no difference in increase in BA or fracture risk rate. Patients with quantitative (-qt) collagen synthesis defects had a higher, although not significant, response to rGH in terms of growth velocity and BMD. Conclusions: In OI patients, the combined rGH-Bp treatment may give better results than Bp treatment alone, in terms of BMD, lumbar spine projected area and growth velocity, particularly in patients with quantitative defects.

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Radial Bending Breaking Resistance Derived by Densitometric Evaluation Predicts Femoral Neck Fracture

Cited by 23 publications

References 17 publications

Dietary Restriction Does Not Adversely Affect Bone Geometry and Mechanics in Rapidly Growing Male Wistar Rats

Dietary Restriction Does Not Adversely Affect Bone Geometry and Mechanics in Rapidly Growing Male Wistar Rats

Longitudinal Changes in BMD and Bone Geometry in a Population-Based Study

GH in combination with bisphosphonate treatment in osteogenesis imperfecta

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