Radial glia-mediated up-regulation of somatostatin in the regenerating adult fish brain

Zupanc, Günther K.H.; Clint, Sorcha C.

doi:10.1016/s0304-3940(01)02061-4

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…This is followed by an increased production of new cells, most of which are granule cell neurons, in specific proliferation zones near the site of lesion (Zupanc and Ott, 1999). During the period of intense proliferation, radial glia fibers and several cell types dramatically upregulate expression of the neuropeptide somatostatin, SRIF (Zupanc, 1999b; Zupanc and Clint, 2001). Next, the density of microglia/macrophages increases in both the lesioned and nonlesioned hemispheres (Zupanc et al, 2003).…”

Section: Involvement Of Radial Glia In Regenerating Adult Fish Brainmentioning

confidence: 99%

Potential role of radial glia in adult neurogenesis of teleost fish

Zupanc

Clint

2003

Glia

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107

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Persistence of radial glia within the adult central nervous system is a widespread phenomenon among fish. Based on a series of studies in the teleost species Apteronotus leptorhynchus, we propose that one function of this persistence is the involvement of radial glia in adult neurogenesis, i.e., the generation and further development of new neurons in the adult central nervous system. In particular, evidence has been obtained for the involvement of radial glia in the guidance of migrating young neurons in both the intact and the regenerating brain; for a possible role as precursor cells from which new neurons arise; and for its role as a source of trophic substances promoting the generation, differentiation, and/or survival of new neurons. These functions contribute not only to the potential of the intact brain to generate new neurons continuously, and of the injured brain to replace damaged cells by newly generated ones, but they also provide an essential part of the cellular substrate of behavioral plasticity.

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Section: Involvement Of Radial Glia In Regenerating Adult Fish Brainmentioning

confidence: 99%

Potential role of radial glia in adult neurogenesis of teleost fish

Zupanc

Clint

2003

Glia

Self Cite

107

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“…During the period of intense proliferation, radial glia fibers and several cell types, tentatively identified as granule cell neurons, astrocytes, and microglia, dramatically up-regulate expression of the neuropeptide somatostatin [Zupanc, 1999b;Zupanc and Clint, 2001]. The up-regulation of somatostatin has been hypothesized to be involved in the generation, migration, and/or differentiation of the new neurons that replace damaged cells.…”

Section: Time Course Relative To Other Regenerative Eventsmentioning

confidence: 99%

“…However, very little is known about the occurrence and the potential role of microglia/macrophages in the process of regeneration in adult teleost fish [Velasco et al, 1995;Jimeno et al, 1999]. Therefore, in the present study we have addressed this issue by using a well-established lesioning paradigm Zupanc and Ott, 1999;Zupanc, 1999b;Zupanc, 2001, 2002;Zupanc and Clint, 2001] in Apteronotus leptorhynchus. To analyze microglia/macrophages, a Lycopersicum esculentum (tomato) lectin staining technique was employed.…”

Section: Introductionmentioning

confidence: 98%

Spatio-Temporal Distribution of Microglia/Macrophages during Regeneration in the Cerebellum of Adult Teleost Fish, <i>Apteronotus leptorhynchus:</i> A Quantitative Analysis

et al. 2003

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In contrast to mammals, adult teleost fish exhibit an enormous capacity to replace damaged neurons with newly generated ones after injuries in the central nervous system. In the present study, the role of microglia/macrophages, identified by tomato lectin binding, was examined in this process of neuronal regeneration in the corpus cerebelli of the teleost fish Apteronotus leptorhynchus. In the intact corpus cerebelli, or after short survival times following application of a mechanical lesion to this cerebellar subdivision, microglia/macrophages were virtually absent. Conversely, approximately 3 days after application of the lesion, the areal density of microglia/macrophages started to increase at and near the lesion site in the ipsilateral hemisphere, as well as in the contralateral hemisphere, and reached maximum levels at approximately 10 days post lesion. The density remained elevated until it reached background levels approximately one month after the injury. By comparing the time course of the appearance of microglia/macrophages with that of other regenerative events occurring within the first few weeks of wound healing in this model system, we hypothesize that one possible function of microglia/macrophages might be to remove debris of cells that have undergone apoptotic cell death at the lesion site.

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“…In adult zebrafish, glial scarring is not associated with brain injury models (Zupanc and Clint, 2001) and fish glia can actively support both fish and mammalian nerve regeneration (Bastmeyer et al, 1993;Bernhardt et al, 1996;Schweitzer et al, 2003;Zukor et al, 2011). Collectively, this raises the possibility that differential regulation of glia behavior contributes to the regenerative capacity of the teleost CNS, in addition to the intrinsic property of regenerating axons themselves.…”

Section: Introductionmentioning

confidence: 99%

Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish

et al. 2012

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Adult zebrafish show a remarkable capacity to regenerate their spinal column after injury, an ability that stands in stark contrast to the limited repair that occurs within the mammalian CNS post-injury. The reasons for this interspecies difference in regenerative capacity remain unclear. Here we demonstrate a novel role for Fgf signaling during glial cell morphogenesis in promoting axonal regeneration after spinal cord injury. Zebrafish glia are induced by Fgf signaling, to form an elongated bipolar morphology that forms a bridge between the two sides of the resected spinal cord, over which regenerating axons actively migrate. Loss of Fgf function inhibits formation of this "glial bridge" and prevents axon regeneration. Despite the poor potential for mammalian axonal regeneration, primate astrocytes activated by Fgf signaling adopt a similar morphology to that induced in zebrafish glia. This suggests that differential Fgf regulation, rather than intrinsic cell differences, underlie the distinct responses of mammalian and zebrafish glia to injury.

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Radial glia-mediated up-regulation of somatostatin in the regenerating adult fish brain

Cited by 13 publications

References 20 publications

Potential role of radial glia in adult neurogenesis of teleost fish

Potential role of radial glia in adult neurogenesis of teleost fish

Spatio-Temporal Distribution of Microglia/Macrophages during Regeneration in the Cerebellum of Adult Teleost Fish, <i>Apteronotus leptorhynchus:</i> A Quantitative Analysis

Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish

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