Radial incision and cutting for refractory benign esophageal stricture

Mizusawa, Takeshi; Kobayashi, Mariko; Terai, Shuji

doi:10.1111/den.13329

Cited by 13 publications

(11 citation statements)

References 5 publications

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“…So, in our present report, we describe the strictures were refractory to conventional EBD. Now, some studies showed ERI is a novel option for refractory rectal/esophageal stricture [6,7,15]. Lee et al [16] evaluated the long-term efficacy of incisional therapy for benign stricture of esophageal anastomotic at the first time; operation-related adverse event has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the management of complex refractory benign strictures after ESD has remained a challenging problem. The ERI technique is recently developed to treat such complex refractory benign strictures, and there are several reports that show ERI is effective for esophageal strictures [6,7]. So, the ERI procedure is a new technique that has been described for the treatment of refractory esophageal strictures.…”

Section: Introductionmentioning

confidence: 99%

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Endoscopic radial incision method for two strictures of the esophagus after endoscopic submucosal dissection: a case report

2020

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Background: The development of severe esophageal stricture after endoscopic submucosal dissection (ESD) for early esophageal carcinoma is not uncommon. Dilation by Savary-Gilliard dilators or balloon dilators is the first-line treatment for such complex refractory benign stricture, but it has a high risk of treatment failure. So far, endoscopic radial incision (ERI) as a new technology for the treatment of post-ESD esophageal stricture has been rarely reported. We report a case, which we designed to assess the efficacy and safety of ERI technology for two severe strictures of the esophagus after ESD. Case presentation: A 67-year-old man had suffered from two complex refractory benign strictures of the esophagus after ESD for early esophageal carcinoma. The patient was refractory to multiple endoscopic balloon dilation (EBD) therapy previously. Thus, the patient underwent ERI successfully and without postoperative complications such as fever, poststernal pain, bleeding, and perforation. During 3 months of follow-up after ERI, the patient had no recurrence of dysphagia. Conclusions: Refractory strictures of the esophagus after ESD are common. ERI is a safe and efficient strategy for treating such multiple refractory esophageal strictures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endoscopic radial incision method for two strictures of the esophagus after endoscopic submucosal dissection: a case report

2020

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“…3 RIC is effective for treating refractory benign esophageal strictures, benign anastomotic stenoses, and CD-associated intestinal strictures. [18][19][20][21] At present, the indications of RIC are not clear.…”

Section: Retrieval Of Retained Capsule Endoscopy By Device-assisted Ementioning

confidence: 99%

Retrieval of retained capsule endoscopy by device‐assisted enteroscopy in patients with cryptogenic multifocal ulcerous stenosing enteritis

Jia

Xie

et al. 2020

J of Digest Diseases

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“…Benign esophageal stricture (BES) is the consequence of esophageal fibrosis, which is caused by a variety of esophageal injuries, such as gastroesophageal reflux, radiotherapy, corrosive substance ingestion, eosinophilic esophagitis and partial esophageal resection (Mizusawa et al, 2019). Recently, esophageal stricture after endoscopic submucosal dissection (ESD) is frequently seen in clinical setting and in standard therapy for early esophageal carcinoma (Ravich, 2017).…”

Section: Introductionmentioning

confidence: 99%

Mitomycin C Inhibits Esophageal Fibrosis by Regulating Cell Apoptosis and Autophagy via lncRNA-ATB and miR-200b

Zhang

Wang

et al. 2021

Front. Mol. Biosci.

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Benign esophageal strictures (BESs) frequently results from esophageal fibrosis. The transformation of fibroblasts into fibrocyte is an important cause of fibrosis. The treatment of fibrosis is challenging. Some previous studies have indicated the antifibrotic effect of mitomycin C (MMC). However, the mechanism of action of MMC and its optimal dose for treatment remains unclear. In the present study, the role of MMC in fighting fibrosis and its mechanism was investigated. Human esophageal fibroblast cells (HEFs)were treated without or with MMC, at 2, 5, 10 μg/ml, combining with mimic lncRNA-ATB, miR-200b inhibitor, rapamycin (RAPA), and 3-Methyladenine (3-MA). The cell viability, and cell apoptosis were evaluated. In addition, expression of apoptosis related proteins (caspase8 and caspase3), autophagy related proteins (LC3II and ATG5) and fibrosis related proteins (α-SMA collagen-1 and TGF-β) were also evaluated. Furthermore, autophagosome was observed by transmission electron microscope. Results showed that the expression of lncRNA-ATB was down-regulated and miR-200b was up-regulated after treated with MMC. And MMC induced cell apoptosis and inhibited cell autophagy. On the other hand, RAPA, mimic lncRNA-ATB and miR-200b inhibitor reduced fibrogenic effect of MMC on HEFs. Collectively, this study suggests that MMC inhibited esophageal fibrosis by regulating cell apoptosis and autophagy via downregulating lncRNA-ATB and upregulating miR-200b.

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Radial incision and cutting for refractory benign esophageal stricture

Abstract: https://onlinelibrary.wiley.com/page/journal/14431661/den13329-sup-0001-vids1.htm a video of this article

Cited by 13 publications

References 5 publications

Endoscopic radial incision method for two strictures of the esophagus after endoscopic submucosal dissection: a case report

Endoscopic radial incision method for two strictures of the esophagus after endoscopic submucosal dissection: a case report

Retrieval of retained capsule endoscopy by device‐assisted enteroscopy in patients with cryptogenic multifocal ulcerous stenosing enteritis

Mitomycin C Inhibits Esophageal Fibrosis by Regulating Cell Apoptosis and Autophagy via lncRNA-ATB and miR-200b

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