Radial Keratotomy in Non-Human Primate Eyes

Histochemical analysis of wound healing in radial keratotomy

“…Although being rather safe in clinical follow up studies (Arrowsmith et al 1983, Waring et a1 1985 the ultrastructural and histocheinical changes were rather dramatic. The finding is consistent with the earlier observations in experiniental animals and in humans (Jester et al 1981, Ingraham et al 1985. The deeper portions of the cornea were healed by fibrous scarring while the superficial wound was filled by epithelial ingrowth.…”

“…The deeper portions of the cornea were healed by fibrous scarring while the superficial wound was filled by epithelial ingrowth. The finding is consistent with the earlier observations in experiniental animals and in humans (Jester et al 1981, Ingraham et al 1985.…”

Meet the corneal myofibroblast: the role of myofibroblast transformation in corneal wound healing and pathology

“…Myofibroblasts also participate in remodeling of the wound through phagocytosis and the expression of transglutaminase (cross links the extracellular matrix) and matrix metalloproteinases (MMPs) 30,31 . In cases of incisional injury, as wound healing proceeds the extracellular matrix is contracted to re‐appose the wound margins followed by the disappearance of myofibroblasts through apoptosis 32–34 …”

“…30,31 In cases of incisional injury, as wound healing proceeds the extracellular matrix is contracted to re-appose the wound margins followed by the disappearance of myofibroblasts through apoptosis. [32][33][34] The replacement of stromal keratocytes by fibroblasts and/or myofibroblasts alters corneal transparency, resulting in corneal haze. 35 The cause of the corneal haze varies with the nature of the wound healing process.…”

Scar tissue orientation in unsutured and sutured corneal wound healing.

“…The presence of ectopic epithelium within unsutured wounds may also affect the organisation of the stromal scar. [5][6][7][8][9][10][11] In a recent study,'2 the scar tissue morphology of unsutured wounds in humans and monkeys was found to vary over the depth of the wound. Anterior regions showed near anatomical, pseudolamellar restoration whereas the midposterior regions were found to be disorganised.…”