Radial Optic Neurotomy for Nonischemic Central Retinal Vein Occlusion

Hayreh, Sohan Singh

doi:10.1001/archopht.122.10.1572-b

Cited by 21 publications

(6 citation statements)

References 8 publications

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“…Soon after the proposal of RON as a potential treatment modality for CRVO in 2001 [13], an emotional debate arose regarding whether the incision of the scleral outlet is a reasonable or dangerous procedure [27][28][29][30]. The potential risk of nerve fiber defects resulting in visual field loss has especially been addressed by many authors [19,27,28].…”

Section: Visual Field Defectsmentioning

confidence: 99%

Treatment of central retinal vein occlusion by radial optic neurotomy in 107 cases

Hasselbach

Ruefer

Feltgen

et al. 2007

Graefes Arch Clin Exp Ophthalmol

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Despite the potential risk of visual field defects, RON seems to be a quite safe procedure. The majority of patients showed rapid normalization of the morphologic fundus findings, with an improvement in VA uncommon for the natural history of CRVO. No significant change in VA was seen in patients with an interval of more than 90 days between the onset of CRVO and RON. A prospective study is warranted for further investigation.

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Section: Visual Field Defectsmentioning

confidence: 99%

Treatment of central retinal vein occlusion by radial optic neurotomy in 107 cases

Hasselbach

Ruefer

Feltgen

et al. 2007

Graefes Arch Clin Exp Ophthalmol

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“…It was reported, however, that the central retinal vein lies temporal to the central retinal artery and both are covered by a common adventitia in the optic nerve [12]. Thus, the radial incision of the optic disc could not decompress the central retinal vein.…”

Section: Discussionmentioning

confidence: 97%

Changes of electroretinogram without improvement of retinal circulation after radial optic neurotomy for central retinal vein occlusion

et al. 2008

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“…Soon after the proposal of RON as a potential treatment modality for CRVO, a debate arose regarding whether the incision of the scleral outlet is a reasonable or dangerous procedure [23], [24]. The potential risk of nerve fiber defects resulting in visual field loss has especially been addressed by many authors [24], [25].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Benefit of Radial Optic Neurotomy in a Rat Model of Glaucoma

et al. 2012

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Radial optic neurotomy (RON) has been proposed as a surgical treatment to alleviate the neurovascular compression and to improve the venous outflow in patients with central retinal vein occlusion. Glaucoma is characterized by specific visual field defects due to the loss of retinal ganglion cells and damage to the optic nerve head (ONH). One of the clinical hallmarks of glaucomatous neuropathy is the excavation of the ONH. The aim of this work was to analyze the effect of RON in an experimental model of glaucoma in rats induced by intracameral injections of chondroitin sulfate (CS). For this purpose, Wistar rats were bilaterally injected with vehicle or CS in the eye anterior chamber, once a week, for 10 weeks. At 3 or 6 weeks of a treatment with vehicle or CS, RON was performed by a single incision in the edge of the neuro-retinal ring at the nasal hemisphere of the optic disk in one eye, while the contralateral eye was submitted to a sham procedure. Electroretinograms (ERGs) were registered under scotopic conditions and visual evoked potentials (VEPs) were registered with skull-implanted electrodes. Retinal and optic nerve morphology was examined by optical microscopy. RON did not affect the ocular hypertension induced by CS. In eyes injected with CS, a significant decrease of retinal (ERG a- and b-wave amplitude) and visual pathway (VEP N2-P2 component amplitude) function was observed, whereas RON reduced these functional alterations in hypertensive eyes. Moreover, a significant loss of cells in the ganglion cell layer, and Thy-1-, NeuN- and Brn3a- positive cells was observed in eyes injected with CS, whereas RON significantly preserved these parameters. In addition, RON preserved the optic nerve structure in eyes with chronic ocular hypertension. These results indicate that RON reduces functional and histological alterations induced by experimental chronic ocular hypertension.

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Radial Optic Neurotomy for Nonischemic Central Retinal Vein Occlusion

Cited by 21 publications

References 8 publications

Treatment of central retinal vein occlusion by radial optic neurotomy in 107 cases

Treatment of central retinal vein occlusion by radial optic neurotomy in 107 cases

Changes of electroretinogram without improvement of retinal circulation after radial optic neurotomy for central retinal vein occlusion

Therapeutic Benefit of Radial Optic Neurotomy in a Rat Model of Glaucoma

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