Radial Scar-Significant Diagnostic Challenge

Abstract

The prevalence of radial scar (RS) is 0.04% in asymptomatic women participating in population screening for breast cancer. It is important to differentiate RS from concomitant malignancies, which occur in 20-30% of patients, or from small stellate carcinomas which give similar radiomorphology. The aim of our study was to evaluate the effectivity of current breast diagnostic methods in distinguishing between real RS, concomitant malignancy and carcinomas imitating RS. Diagnosis of RS was set up in 61 cases by mammography. Forty-four patients underwent surgical excision: histology showed benign or malignant lesions in 28 and 16 cases, respectively. A series of negative results at follow-up proved the benign nature of the lesion in further 11 cases. Six patients were not available for follow-up. Results of mammography, physical examination, ultrasonography and cytology were evaluated and were compared in 39 benign and 16 malignant cases. Results of examinations were reported on the BI-RADS scale ranging from 1 to 5. The mean categorical scores of all diagnostic processes were around the level of borderline lesions: mammography: 3.49, ultrasonography: 3.06, cytology: 2.47 and physical examination: 1.67. The average age of the patients in the benign and malignant groups were the same: 58 years. The two groups did not differ significantly over either distribution of coded mammographical results (p = 0.2092), or the distribution of mammographical parenchyma density patterns (p = 0.4875). However, the malignant and benign groups differed significantly from each other over the distribution of coded ultrasonographic (p = 0.0176) and cytological (p < 0.0001) results. In conclusion, in the preoperative diagnosis of asymptomatic "black-stars", mammography detects the non-palpable lesions, and ultrasonography together with cytology proved better in the analysis, provided FNAB is US guided. Due to the complex diagnostic approach the nature of the "black stars" is known in the majority of cases prior to the surgical biopsy.

Breast Cancer Screening and Diagnosis

“…Other histologies that may require additional tissue samples include mucin-producing lesions, potential phyllodes tumor, papillary lesions, radial scars, or other histologies of concern to the pathologist. 77,83,84,90 This recommendation is supported by results of studies showing an underestimation of cancer when atypical hyperplasia and LCIS are diagnosed by CNB. [91][92][93][94][95][96] However, situations occur (e.g., select cases of LCIS, atypical lobular hyperplasia, papillomas, fibroepithelial lesions, radial scars) in which close observation may be substituted for excisional biopsy in select patients.…”

“…[91][92][93][94][95][96] However, situations occur (e.g., select cases of LCIS, atypical lobular hyperplasia, papillomas, fibroepithelial lesions, radial scars) in which close observation may be substituted for excisional biopsy in select patients. 83,90,[97][98][99]…”

B3 Lesions: Radiological Assessment and Multi-Disciplinary Aspects

“…Many LIN lesions have no characteristic imaging features: They may incidentally occur in or adjacent to areas of micro- distortion [43,45]. Figures 5 and 6 give examples of mammographic and sonographic appearances of RSLs.…”

“…Even though the risk of malignancy is higher with the former imaging features, the latter may also be associated with malignancy (invasive or DCIS) in up to 20% of the cases. Unless an architectural distortion corresponds to scarring or is proven as superimposition (after additional views), no reliable mammographic sign exists that could allow the exclusion of malignancy [40][41][42][43]. On US, radial scars may be associated with a hypoechoic (mostly small) mass; they may exhibit an architectural distortion or shadowing [43][44][45].…”

Radiäre Narbe: eine unmögliche radiologische Diagnose

“…Vor dem Hintergrund des mastopathischen Gewebes bleibt die Mehrzahl der kleinen radiären Narben unentdeckt. Entsprechend gering ist die Prävalenz der strahligen Narbe beim Screening [19,20]. Die klassischen radiologischen Kriterien fanden Bouté et al [21] in einer retrospektiven Studie an 113 radiären Narben nur in knapp der Hälfte der Fälle (48 %) erfüllt.…”