Radiation and Small Bowel Complications in Cervical Carcinoma Therapy

Management of Radiation Injuries to the Bowel Associated with Treatment of Uterine Carcinoma by Radiotherapy: Preliminary Communication

“…those over 70 years of age, with advanced disease, diabetes, hypertension, small physique or obesity (Maruyama et al 1974). Of the 12 patients discussed here, one was over 70 years of age, 2 had T3 tumours of the cervix, 2 were insulin-requiring diabetics and one suffered from hypertension.…”

Hypokalemic Myopathy Associated with Radiation Enteropathy

“…Intestinal disturbances induced by radia tion therapy include small intestinal irrita tion causing nausea and vomiting, abdomi nal pain, ulceration, perforation, obstruction, abscess formation, fistula, bleeding and mal-absorption [7], When the whole abdominal radiation is above 2,100 rad, crypt degenera tion and shortening of the villi can occur [9], Since the terminal ileum is fixed in the pelvic cavity, it has a tendency to have postradia tion injury most frequently. Since the bile acid is mainly absorbed by the terminal ileum, radiation therapy can cause malab sorption of the bile acid and steatorrhea [4], Previous abdominal surgery, hypertension and diabetes [13] can increase the chance of radiation enteropathy [4], For the treatment of intestinal damage by radiation it is important to rest the gastroin testinal tract, and total parenteral nutrition is helpful to supply enough nutrition [5], In our case prolonged total parenteral nutrition was continued for the total duration of 1.5 months.…”

Californium-252 Neutron Curietherapy for Advanced Cervical Cancer

“…The other patient had stage IV disease with severe long-standing malignant hyperten sion and with uremia. The consequence of these dis eases may have been to interfere with the promptness and capability for reoxygenation of the hypoxic tumor cells due to micro-pathology of small vessels [18,29,30]. The integrity and elasticity of the small vascular tree and its responsiveness may therefore be important for in vivo rcoxygenation to occur.…”

“…There was no significant differences in the two series of patients treated, in the frequency in which elevated blood pressure was found (table III). Table III shows the presence or absence of two marker medical diseases which could alter or affect radiation response, i.e., diabetes mellitus and hyper tension [18,29,30]. The data presented in table III shows that 3/20 or 15% of the early series and 4/22 or 18% of the delayed series had diabetes mellitus.…”