Radiation and the Small Intestine

Churnratanakul, S; Wirzba, B.; Lam, TP; Walker, K.; Fedorak, Richard N.; Thomson, Abr

doi:10.1159/000171239

Cited by 17 publications

(1 citation statement)

References 64 publications

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“…The intestine is the earliest hit and most severely damaged tissue in the irradiation setting, and thus understanding both early and late injury responses has been a key interest in the field. 89 Additionally, acute irradiation damage has been used as a mechanism to study pathways involved in intestinal recovery, and, as mentioned above, has been a key tool in studying activation of QSCs. The acute irradiation response can be distilled into two stages.…”

Section: A Crypt Post-irradiation Recovery Modelmentioning

confidence: 99%

Unraveling intestinal stem cell behavior with models of crypt dynamics

2014

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The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated. Recent discoveries have started to clarify the nature of ISCs, but many questions remain. This review discusses the current advances and controversies of ISC biology as well as theoretical compartmental models that have been coupled with in vivo experimentation to investigate the mechanisms of ISC dynamics during homeostasis, tumorigenesis, repair and development. We conclude our review by discussing the key lingering questions in the field and proposing how many of these questions can be addressed using both compartmental models and experimental techniques.

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Section: A Crypt Post-irradiation Recovery Modelmentioning

confidence: 99%

Unraveling intestinal stem cell behavior with models of crypt dynamics

2014

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Radiation Effects on Normal Intestinal Tissue

Thomson

Churnratanakul

Wirzba

et al. 1992

Modern Concepts in Gastroenterology Volume 3

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Severe late radiation enteropathy is characterized by impaired motility of proximal small intestine

et al. 1994

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Late radiation enteropathy (LRE) is a serious disorder, and therapeutic progress has thus far been hampered by insufficient understanding of the pathogenesis. This prospective study addresses whether alterations in proximal intestinal motility can predict the clinical severity of this disorder. Forty-one consecutive patients with chronic abdominal complaints after radiotherapy for gynecological cancer were examined by prolonged ambulatory manometry. Twenty-seven healthy adults served as controls. Impaired fasting motility was found in 12 of 41 patients (29%), and attenuated postprandial motor response after a liquid-solid meal was seen in 10 of 41 patients (24%). Postprandial delay of the migrating motor complex (MMC) was a good predictor of the degree of malnutrition (Cox regression, P < 0.01), and intensity of the MMC and postprandial motility index explained 69% (P < 0.001, multiple regression) of the variability in degree of malnutrition, assessed by weight loss and serum albumin level. The typical presentation of severe LRE was clinical symptoms suggesting intestinal pseudoobstruction, malnutrition, failure of a liquid-solid meal to induce postprandial motility, and delayed initiation and reduced intensity of MMC during nocturnal fasting. Prolonged ambulatory manometry was useful for detection of dysmotility in patients with symptoms of LRE and impaired motility of proximal small intestine seems to be a key factor in the pathogenesis of severe LRE.

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Radiation and the Small Intestine

Cited by 17 publications

References 64 publications

Unraveling intestinal stem cell behavior with models of crypt dynamics

Unraveling intestinal stem cell behavior with models of crypt dynamics

Radiation Effects on Normal Intestinal Tissue

Severe late radiation enteropathy is characterized by impaired motility of proximal small intestine

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