Radiation-associated peritoneal angiosarcoma

Abstract

Angiosarcomas account for only 1-2% of all soft tissue sarcomas, with the most common site of origin being in the head and neck region. Peritoneal angiosarcoma is an extremely rare tumour and few cases have been reported previously. Presentation of peritoneal angiosarcoma can be very variable, hence making diagnosis difficult. Herein, we review the current literature and describe a rare case of a patient who presented with haemorrhagic ascites, 17 years after radiotherapy for endometrial carcinoma and was subsequently diagnosed with peritoneal angiosarcoma. Due to extensive disease, surgery was not a viable option. She was started on palliative chemotherapy, but despite treatment, her condition deteriorated further and she eventually passed away. We highlight the diagnostic challenges and considerations in these patients as well as current treatment and management options available.

Dual unifocal primary Epithelioid Angiosarcoma: A case report and review of the literature unveiling a rare genre of neoplasia

“…In terms of executing a curative treatment, evidence-based therapeutic options for angiosarcomas are currently limited [ 28 ]. So far, treatment modalities for Epithelioid Angiosarcoma mainly consist of surgery, chemotherapy, radiotherapy, either individually or in a unified approach.…”

Primary Peritoneal Angiosarcoma Metastatic to Liver and Bone without History of Radiation Therapy

“…It is proposed that the two are ultimately very similar in histology, in disease pattern, and in mutation profile [ 4 ]. Other literature has found that MYC gene amplification may be more distinct for postradiation malignancy compared to primary malignancy [ 7 ]. This difference, however, does not appear to significantly impact the clinical disease course.…”

Peritoneal epithelioid angiosarcoma

“…Evidence-based treatments of angiosarcomas are scarce. [ 8 ] According to Seo et al, [ 8 ] radical resection is considered for radiation-induced angiosarcomas, and systemic chemotherapy is for inoperable, locally advanced or metastatic angiosarcomas. However, in our case, the patient was in the state of shock after the operation, so the surgical intervention and the chemotherapy were comparably unsuitable treatments.…”