Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Singh, Baljit; Sharma, Vikrant; Kumar, Anil; Kumar, Sanjay

doi:10.1016/j.ijbiomac.2009.08.001

Cited by 16 publications

(6 citation statements)

References 37 publications

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“…This observation was corresponding to swelling trends observed in different pH medium [32]. Singh et al [33] reported that the tetracycline hydrochloride drug and dynamics of model antibiotic drug rifampicin were released from the modified psyllium with methacrylamide through radiation crosslinked polymerization. The release dynamics of rifampicin was a broad-spectrum antibiotic used to treat Mycobacterium contagions, leprosy and with tuberculosis and also has a role in the handling of methicillin-resistant Staphylococcus aureus in combination with fusidic acid.…”

Section: Drug Delivery Studiessupporting

confidence: 65%

“…The liquefied drug diffuses into the external discharging medium. More the swelling, faster the release of drug from the polymer matrix will occur [33]. Singh et al [34] studied that the tetracycline hydrochloride drug was released from the improved psyllium with methacrylamide poly (MAAm) polymeric networks through using N,N-MBAAm as cross-linker and ammonium persulfate (APS) as initiator which used in colon specific drug delivery.…”

Section: Drug Delivery Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Psyllium Mucilage and Its Use in Pharmaceutical Field: An Overview

Kumar¹,

Pandey²,

Kumar³

et al. 2017

Curr Synthetic Sys Biol

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Plantago psyllium mucilage or Plantago psyllium ovate is a food grade natural polysaccharide obtained from Plantago psyllium and its mucilage is calm of natural arabinoxylan (arabinose 22.6% and xylose 74.6%). Psyllium mucilage is extracted from psyllium husk. Graft copolymerization is one of the best methods for modifying psyllium, which impart certain functional properties to psyllium without destroying its basic properties. The grafting is initiated through the formation of the free radical centers on the polymer backbone. Psyllium has wide application in many health problems, particularly cholesterol control, colon cancer prevention, high sugar levels in blood and widely used as a laxative.

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Section: Drug Delivery Studiessupporting

confidence: 65%

Section: Drug Delivery Studiesmentioning

confidence: 99%

Psyllium Mucilage and Its Use in Pharmaceutical Field: An Overview

Kumar¹,

Pandey²,

Kumar³

et al. 2017

Curr Synthetic Sys Biol

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“…12 An attempt has been made to crosslink the husk with various synthetic polymers. Singh B. et al 13 modified husk with methacrylamide via 60 Co gamma radiation crosslinked polymerization for formulation of sustained release rifampicin hydrogel. 13 Polyvinyl alcohol PVA is a hydrophilic polymer which is widely used in formulation development due to its flexible processability, pH and temperature stability, non-toxicity, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium

Ale,

Nainwal,

Butola

et al. 2023

Ind. J. Pharm. Edu. Res.

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Introduction: Diclofenac Sodium (DS), a Non-Steroidal Anti-Inflammatory Drug (NSAID) is widely used in inflammation and pain management. However, the drug has a short half-life of 1.2-2 hr therefore, frequent administration of DS is required. In this research paper Inter-Penetrating Network (IPN) microspheres of Diclofenac sodium were made using Isabgol husk mucilage and Polyvinyl Alcohol (PVA) to prolong the release of diclofenac sodium. Isabgol husk is widely explored as a natural, economical, biocompatible, and biodegradable polymer for the development of a modified-release drug delivery system. Materials and Methods: IPN microspheres were prepared using Isabgol husk mucilage and Polyvinyl alcohol by emulsion cross-linking method in the presence of DL glyceraldehyde as a cross-linker. Evaluation: Fourier Transform Infrared (FTIR) spectroscopy was performed to confirm the formation of an interpenetrating network. The chemical stability of the drug and its molecular dispersion in the IPN was validated by X-ray Diffraction (XRD) analysis. The prepared microspheres were evaluated for % yield, drug loading, entrapment efficiency, surface morphology, swelling index and in vitro drug release. Results: The percentage yield and drug entrapment efficiency of the formulations were found in between 66.33 to 95.345%, and 40.24 to 68.12% respectively. The SEM and light microscopy studies confirmed the formation of spherical IPN microspheres. The model kinetics of in vitro release data found Korsmeyer-Peppas as the best-fit model for drug release from IPN microspheres.

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“…As swelling properties, drug release can be controlled adjusting the crosslinking degree [17]. Therefore, films with correct structural relationship between hydrophilicity and crosslinking degree can release drugs with a sustained behavior [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%