Radiation dose distribution in the teeth, maxilla, and mandible of patients with oropharyngeal and nasopharyngeal tumors who were treated with intensity‐modulated radiotherapy

Abstract

A dose distribution map was generated based on the estimated doses received, which could allow prediction of the areas most affected by radiation and facilitate further correlations with dental complications after radiotherapy. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.

Predicting radiation dosimetric distribution in different regions of the jaw in patients receiving radiotherapy for squamous cell carcinoma of the tonsil

“…These trends include a higher radiation dose for posterior teeth (molars followed by premolars) than for anterior teeth and greater radiation exposure of dental groups ipsilateral to the tumor than of dental groups contralateral to the tumor. 5,16,17,19,20 Tumor size was also found to be a predictive factor in our models for greater expected radiation dose, just as previous studies have found that larger tumors have greater radiation doses delivered to the anterior teeth and to the entire mandible (regardless of tumor laterality). 16,20 In our models, overall stage was a predictive variable for maximum radiation dose.…”

“…5,16,17,19,20 Tumor size was also found to be a predictive factor in our models for greater expected radiation dose, just as previous studies have found that larger tumors have greater radiation doses delivered to the anterior teeth and to the entire mandible (regardless of tumor laterality). 16,20 In our models, overall stage was a predictive variable for maximum radiation dose. Although an earlier study had not found a relationship between cervical nodal metastasis and mandibular radiation dose, it is possible that this conclusion was due in part to the small size of the sample group.…”

“…5,[16][17][18][19][20] To our knowledge, this is the first article to generate models that could be used to predict expected radiation dose without requiring additional contouring. Previous studies have retrospectively determined the radiation dosimetric distribution by contouring individual tooth-bearing regions in radiation treatment plans.…”

“…Previous studies have retrospectively determined the radiation dosimetric distribution by contouring individual tooth-bearing regions in radiation treatment plans. 5,[16][17][18][19][20] To our knowledge, this is the first article to generate models that could be used to predict expected radiation dose without requiring additional contouring. Reassuringly, the expected radiation doses from our predictive models followed similar trends as these studies that delineated individual teeth in the radiation treatment plans for base of tongue (BOT), tonsil, and hypopharyngeal tumors.…”

Dental extractions for preradiation dental clearance and incidence of osteoradionecrosis in patients with nasopharyngeal carcinoma treated with intensity‐modulated radiotherapy

“…Parahyba el al. reported on the radiation dose distribution of nasopharyngeal patients treated with IMRT, and found that molar regions of the maxilla and mandible would most likely receive high doses of radiation due to its proximity to the nasopharynx . This would put the molar regions in these patients at the highest risk of developing ORN.…”