Radiation dose perturbation at the tissue interface with PEEK and Titanium bone implants: Monte Carlo simulation, treatment planning and film dosimetry

Katsifis, Georgio; McKenzie, David R.; Hill, Robin; Connor, Michael O’; Milross, Christopher G.; Suchowerska, Natalka

doi:10.1016/j.radphyschem.2022.110398

Cited by 3 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 5,8–10 ] Poly‐ether‐ether‐ketone (PEEK) is a thermoplastic polymer, with biomechanical properties similar to those of bone, and has been proposed as an alternative to titanium for implants, causing less interference for both imaging and radiation therapy. [ 5,8,11,12 ] PEEK is chemically inert but in its natural state has hydrophobic characteristics [ 5,13 ] that may prevent osseointegration. [ 14,15 ] Plasma immersion ion implantation (PIII) is a surface modification technique, which utilizes high ion energy bombardment to impart hydrophilic properties and provides reactive sites in carbon‐based polymers, and allows better adhesion of bone on‐growth and encouraging stronger binding of biomolecules, for example, bone morphogenic proteins that may assist bone growth.…”

Section: Introductionmentioning

confidence: 99%

“…[5,6] Following integration with the body, outlining the boundaries of a PEEK scaffold can prove difficult because the X-ray attenuation properties of prebone tissues are very close to those of PEEK. [11,24] Here, we use innovative approaches to improve both data collection and data analysis to investigate the osteoconduction in the PEEK scaffold after implantation in the sheep.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Micro‐CT Analysis of Implanted Poly‐Ether‐Ether‐Ketone Scaffolds: Plasma Immersion Ion Implantation Increases Osteoconduction

et al. 2023

Self Cite

View full text Add to dashboard Cite

Bone diseases such as osteosarcoma often require aggressive removal of bony tissue. [1] After surgery, bone function is restored by the hemostatic stimulation of the local bone to fill the defect. [2] In critical-sized defects, this mechanism is insufficient to fill bone loss and reconstruction using a bone graft from another part of the skeleton or a prosthetic bone implant is needed. [3,4] Titanium plates have been used to bridge bone segments but because of the differences in elastic modulus, implant failure from stress-shielding osteolysis may ultimately occur. [5][6][7] For cancer patients requiring radiation therapy, titanium causes unwanted shielding and scattering of the radiation, compromising treatment quality. [5,[8][9][10] Poly-ether-etherketone (PEEK) is a thermoplastic polymer, with biomechanical properties similar to those of bone, and has been proposed as an alternative to titanium for implants, causing less interference for both imaging

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Micro‐CT Analysis of Implanted Poly‐Ether‐Ether‐Ketone Scaffolds: Plasma Immersion Ion Implantation Increases Osteoconduction

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium

Ward,

Damante,

Wilson

et al. 2024

J Neurooncol

View full text Add to dashboard Cite

Purpose Spine metastases are a major burden of oncologic care, contributing to substantial morbidity. A well-established treatment paradigm for patients with metastatic epidural spinal cord compression includes separation surgery followed by stereotactic body radiotherapy (SBRT). Innovations in implant technology have brought about the incorporation of Carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation for spinal fixation. We present our experience of CFR-PEEK instrumentation, comparing outcomes and complication profiles with a matched cohort of titanium instrumented cases for spine metastatic disease. Methods Oncology patients who underwent spinal fusion for metastatic spine disease from 2012 to 2023 were retrospectively reviewed. Ninety-nine cases with CFR-PEEK fusions were case-control matched with 50 titanium controls (2:1 ratio) based upon primary tumor type and spinal instability neoplastic score (SINS) location. Demographic, clinical, radiographic and progression free survival (PFS) were analyzed. Results In the study years, 263 patients underwent spinal decompression and fusion, for which 148 patients met predetermined inclusion criteria. Of these, 49 had titanium instrumentation, and 99 had CFR-PEEK. Complication profiles, including hardware failure and infection were similar between the groups. There was no significant difference in PFS between all CFR-PEEK and titanium patients (143 days versus 214 days; p = 0.41). When comparing patients in which recurrence was noted, CFR-PEEK patients had recurrence detected two times earlier than titanium patients (94 days versus 189 days; p = 0.013). Conclusion In this case matched cohort, CFR-PEEK demonstrated decreased overall PFS suggestive of earlier local recurrence identification. Long-term studies are warranted for better evaluation of the impact on survival and systemic disease progression.

show abstract

The research status and future direction of polyetheretherketone in dental implant —A comprehensive review

HAO,

SHI,

ZHANG

et al. 2024

Dent. Mater. J.

View full text Add to dashboard Cite

Radiation dose perturbation at the tissue interface with PEEK and Titanium bone implants: Monte Carlo simulation, treatment planning and film dosimetry

Cited by 3 publications

References 18 publications

Micro‐CT Analysis of Implanted Poly‐Ether‐Ether‐Ketone Scaffolds: Plasma Immersion Ion Implantation Increases Osteoconduction

Micro‐CT Analysis of Implanted Poly‐Ether‐Ether‐Ketone Scaffolds: Plasma Immersion Ion Implantation Increases Osteoconduction

Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium

The research status and future direction of polyetheretherketone in dental implant —A comprehensive review

Contact Info

Product

Resources

About