Radiation Doses in Interventional Radiology Procedures: The RAD-IR Study Part I: Overall Measures of Dose

Miller, Donald L.; Balter, Stephen; Cole, Patricia E.; Lu, Hollington T.; Schueler, Beth A.; Geisinger, Michael A.; Berenstein, Alejandro; Albert, Robin; Georgia, Jeffrey D.; Noonan, Patrick T.; Cardella, John F.; George, James St.; Russell, Eric J.; Malisch, Tim W.; Vogelzang, Robert L.; Miller, George; Anderson, J. A.

doi:10.1097/01.rvi.0000079980.80153.4b

Cited by 337 publications

(241 citation statements)

References 43 publications

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“…1,2 The procedure is performed in order to guide small instruments such as catheter through blood vessels or other pathways in the body. The tissues near the region of treatment often get exposed to the penetrative X-rays leading to harmful side effects to both internal and superficial organs.…”

Section: Introductionmentioning

confidence: 99%

P(VDF-TrFE)/ZrO2 Polymer-Composites for X-ray Shielding

et al. 2016

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Poly(vinylidene fluoride -tryfluorethylene) [P(VDF-TrFE)] copolymers were mixed with zirconia nanoparticles. The investigation was conducted with the intention to produce nanocompounds with potential to be used as protective patient shielding in radiological procedures. Polymer based nanocomposites with 1, 2, 3, 5 and 10 wt% of ZrO 2 nanoparticles were prepared using sol-gel route with zirconium butoxide as the precursor for zirconium oxide nanoclusters. UV-Vis and FTIR spectrometry and differential scanning calorimetry (DSC) were used to characterize the composite samples. We observed a more homogeneous distribution of ZrO 2 nanoparticles encapsulated by methyl methacrylate (MMA) into the polymeric matrix, when compared to composites made without the use of surface modifiers from methacrylate group. Apparently, this property is related to the absence of the strong MMA absorption band at 1745 cm -1 , attributed to C=O bond, in the P(VDF-TrFE)/ZrO 2 -MMA nanocomposites. The radiation damage due to high dose exposuring was performed for gamma doses ranging from 100 kGy to 1,000 kGy. The radiation shielding characterization conducted using x-rays with effective energy of 40 keV has demonstrated that composites with 10% of ZrO 2, and only 1.0 mm thick, can attenuate 60% of the x-rays beam.

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Section: Introductionmentioning

confidence: 99%

P(VDF-TrFE)/ZrO2 Polymer-Composites for X-ray Shielding

et al. 2016

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“…With the possible exception of technologists who began working before age 17 years, we found no evidence that more recent radiation dose levels increase breast cancer risk; however, the possibility of elevated cancer risks from fluoroscopically guided diagnostic and interventional procedures is of growing concern. [42][43][44][45] Medical radiation workers and their employers should be cognizant of atypical radiation exposures and should take precautions to minimize them. Workers also should inform their health care providers about their occupational exposure.…”

Section: Resultsmentioning

confidence: 99%

A nonsynonymous single‐nucleotide polymorphism in the PDZ‐Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans

Dong

et al. 2006

Cancer

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BACKGROUNDBased on in vitro studies, Rho guanine nucleotide exchange factors (RhoGEFs) are key regulators of mitogenic and transforming pathways. At least 1 family member, PDZ‐RhoGEF, also integrates signaling between monomeric Rho G proteins and heterotrimeric G proteins through a so‐called regulator of G‐protein signaling (RGS) domain. Recently, the authors reported that 3 single‐nucleotide polymorphisms (SNPs) in 2 members of the RGS family were associated with significant reductions in the risk of cancer.METHODSFor the current report, the authors studied the risk of lung cancer associated with a nonsynonymous SNP (rs868188; Ser1416Gly) in PDZ‐RhoGEF in a large lung cancer case‐control study of 2260 Caucasians and 369 Mexican Americans.RESULTSCompared with individuals who had the wild‐type genotype (AA), Mexican Americans with the variant genotypes (AG and GG) had a significantly reduced risk for lung cancer (odds ratio [OR], 0.57; 95% confidence interval [95%CI], 0.34‐0.94). The protective effect appeared to be more evident in younger individuals (OR, 0.42; 95%CI, 0.20‐0.91), men (OR, 0.36; 95%CI, 0.18‐0.71), and ever smokers (OR, 0.50; 95%CI, 0.29‐0.88). A joint effect was observed between Ser1416Gly and polymorphisms in 2 cell‐cycle control genes: p53 (intron 3) and cyclin D1 (CCND1). Tallying the variant alleles of the 4 RGS gene SNPs, a gene‐dosage effect was apparent. Compared with individuals who had <3 variant alleles, patients with ≥3 variant alleles had a 51% reduction in lung cancer risk (OR, 0.49; 95%CI, 0.28‐0.88).CONCLUSIONSTo the authors' knowledge, this is the first epidemiological study to link PDZ‐RhoGEF polymorphisms with cancer risk. The results suggest that there are interactions between RGS2, RGS6, and PDZ‐RhoGEF and validate this family of proteins as key regulators of tumorigenesis. Cancer 2006. © 2006 American Cancer Society.

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“…The numbers of lengthy complex interventions such as embolizations, percutaneous porto-systemic shunt placements, invasive electrophysiology, and catheter ablations have continuously grown over the last years. With some of these procedures deterministic radiation effects such as erythema or loss of hair have been reported (84,85). These damages are-regardless of patient age, morbidity, or life expectancy-intolerable and must be avoided by all means.…”

Section: Safety Aspectsmentioning

confidence: 99%

MR‐guided intravascular interventions: Techniques and applications

Bock

Wacker

2008

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) offers several advantages over other imaging modalities that make it an attractive imaging tool for diagnostic and therapeutic procedures. This tremendous potential of MRI has provided the rationale for increased attention toward MR-guided endovascular interventions. MR guidance has been used recently to navigate endovascular catheters and deliver stents, vena cava filters, embolization materials, and septum closure devices. However, its potential goes beyond just copying existing procedures toward the development of new minimally invasive techniques that cannot be performed with conventional guiding techniques. Because of technical limitations and safety issues associated with some of the currently available devices, a limited number of clinical studies have been performed so far. The overall success for this developing field requires considerable interdisciplinary research within both the interventional and the MR community. Only through a combined effort can this complex technology find its way into clinical practice. This review discusses the hardware and software improvements that have helped to advance endovascular interventions under MR imaging guidance from a pure research tool to become a clinical reality. In addition, technical and safety issues specific to endovascular MR image guidance will be described and practical applications will be shown that take advantage of the benefits of MR for endovascular interventions.

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Radiation Doses in Interventional Radiology Procedures: The RAD-IR Study Part I: Overall Measures of Dose

Cited by 337 publications

References 43 publications

P(VDF-TrFE)/ZrO2 Polymer-Composites for X-ray Shielding

P(VDF-TrFE)/ZrO2 Polymer-Composites for X-ray Shielding

A nonsynonymous single‐nucleotide polymorphism in the PDZ‐Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans

MR‐guided intravascular interventions: Techniques and applications

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