Radiation Dosimetry Using Alanine and Electron Paramagnetic Resonance (EPR) Spectroscopy: A New Look at an Old Topic

Goodman, B. A.; Worasith, Niramon; Ninlaphruk, Sumalee; Mungpayaban, Harinate; Deng, Wen

doi:10.1007/s00723-016-0855-8

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…where D w Q 0 is the true absorbed dose to water, relative to a reference beam quality (Q 0 ), and D w Q is the absorbed dose to water measured by alanine dosimeters after irradiation with X-ray beam quality (Q). This method can be applied for irradiations at doses lower than 10 kGy, while at higher doses, the correction factor should be firstly applied to the dosimeter's response, due to the non-linearity of the latter versus absorbed dose to water (Goodman et al, 2017), thus, absorbed dose to water can be then correctly estimated using the EPR system's calibration curve.…”

Section: Correction Factorsmentioning

confidence: 99%

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Absorbed dose to water determination for kilo-voltage X-rays using alanine/EPR dosimetry systems

Nasreddine

Kuntz²,

Bitar

2021

Radiation Physics and Chemistry

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Alanine's relative response to kilo-voltage X-rays, compared to 60 Co reference quality beam, was studied in this work, in order to determine correction factors to be applied to alanine's response when irradiated with low to medium energy X-rays (up to 300 keV).The relative response to kilo-voltage X-rays of Aerial's alanine dosimeters was determined by three distinct methods: experimental measurements using alanine dosimeters and a calibrated PTW Farmer 30013 ion chamber, Monte Carlo simulations using MCNPX code and finally, analytical calculations based on weighting of X-ray spectra by NIST's published mass energy absorption coefficients. Two sets of X-ray beam qualities, covering high voltages ranging from 50 kV up to 280 kV, were used to study the energy dependence of the alanine dosimeter's response. Obtained results were consistent within 2.1% (average standard deviation at k = 1).

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Section: Correction Factorsmentioning

confidence: 99%

“…4. However, it was reported in (Goodman et al, 2017) that alanine's response is non-linear versus absorbed dose to water for doses higher than 10 kGy, thus, one should be careful to apply the adequate correction factor to the dosimeter's response rather than apply it directly to the measured dose for doses higher than 10 kGy.…”

Section: Experimental Measurementsmentioning

confidence: 99%

Absorbed dose to water determination for kilo-voltage X-rays using alanine/EPR dosimetry systems

Nasreddine

Kuntz²,

Bitar

2021

Radiation Physics and Chemistry

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“…We sought to develop a simple, quick, and effective methodology for radiation dosimetry based on a nanoplasmic colorimetric assay. Similar sensing technologies have proven to have significant benefits over conventional sensors such as high biocompatibility, good stability, high sensitivity, and low cost. , In contrast, traditional radiation dosimeters, such as the metal–oxide–semiconductor field-effect transistor (MOSFET) dosimeter, thermoluminescent dosimeter (TLD), and quartz fiber dosimeter (QFD), , usually require sophisticated and expensive fabrication technology, separate readout instruments, and professional operators. These drawbacks may limit their application in resource-constrained areas or countries.…”

Section: Introductionmentioning

confidence: 99%

Dual-Color Plasmonic Nanosensor for Radiation Dosimetry

Tao

Liu

et al. 2020

ACS Appl. Mater. Interfaces

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Radiation dosimeters are critical for accurately assessing the levels of radiation exposure of tumor sites and surrounding tissues and for optimizing therapeutic interventions as well as for monitoring environmental exposure. To fill the need for a simple, user-friendly, and inexpensive dosimeter, we designed an innovative colorimetric nanosensor-based assay for detecting ionizing radiation. We show that hydroxyl radicals generated by ionizing radiation can be used to etch gold nanorods (AuNRs) and silver nanoprisms (AgNPRs), yielding reproducible color changes for radiation dose detection in the range of 50-2000 rad, broad enough to cover doses used in hyperfractionated,

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“…It was almost immediately realized that solid-state L-α-alanine is particularly interesting for dosimetric applications 4 and today it is fully recognized as a secondary radiation dose standard. [5][6][7][8] In view of this, considerable effort has been devoted to the understanding of the radiation chemistry of alanine and to reliable simulations of its powder EPR spectrum at room temperature (RT).…”

Section: Introductionmentioning

confidence: 99%

“…The first reports of the radiation-induced electron paramagnetic resonance (EPR) spectrum of this amino acid date from the early 1960s, , when alanine and other amino acids were employed to gain insight into the nature of hyperfine (HF) interactions in organic molecules. It was almost immediately realized that solid-state l -α-alanine is particularly interesting for dosimetric applications, and today it is fully recognized as a secondary radiation dose standard. − In view of this, considerable effort has been devoted to the understanding of the radiation chemistry of alanine and to reliable simulations of its powder EPR spectrum at room temperature (RT).…”

Section: Introductionmentioning

confidence: 99%

ENDOR-Induced EPR of Disordered Systems: Application to X-Irradiated Alanine

et al. 2018

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The electron paramagnetic resonance (EPR) spectra of radiation-induced radicals in organic solids are generally composed of multiple components that largely overlap due to their similar weak g anisotropy and a large number of hyperfine (HF) interactions. Such properties make these systems difficult to study using standard cw EPR spectroscopy even in single crystals. Electron-nuclear double-resonance (ENDOR) spectroscopy is a powerful and widely used complementary technique. In particular, ENDOR-induced EPR (EIE) experiments are useful for separating the overlapping contributions. In the present work, these techniques were employed to study the EPR spectrum of stable radicals in X-irradiated alanine, which is widely used in dosimetric applications. The principal values of all major proton HF interactions of the dominant radicals were determined by analyzing the magnetic field dependence of the ENDOR spectrum at 50 K, where the rotation of methyl groups is frozen. Accurate simulations of the EPR spectrum were performed after the major components were separated using an EIE analysis. As a result, new evidence in favor of the model of the second dominant radical was obtained.

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Radiation Dosimetry Using Alanine and Electron Paramagnetic Resonance (EPR) Spectroscopy: A New Look at an Old Topic

Cited by 12 publications

References 22 publications

Absorbed dose to water determination for kilo-voltage X-rays using alanine/EPR dosimetry systems

Absorbed dose to water determination for kilo-voltage X-rays using alanine/EPR dosimetry systems

Dual-Color Plasmonic Nanosensor for Radiation Dosimetry

ENDOR-Induced EPR of Disordered Systems: Application to X-Irradiated Alanine

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