Radiation effect studies on anticancer drugs, cyclophosphamide and doxorubicin for radiation sterilization

Influence of e-Beam Irradiation on Sulfamethoxazole in Solid State

“…A similar interpretation of the color changes has been given by other authors. 31,32 The above-proposed mechanism of SMX radiolysis incited by e-beam irradiation is different from that proposed earlier for this compound radiolysis caused by gamma irradiation. 16 Although in both cases, the radiolysis was found to include the breaking of the S-N bond, gamma irradiation was found to attack the isoxasole ring and thus lead to formation of two products: carbon oxide sulfide and acetaldehyde.…”

Fabrication of biodegradable polymeric micro chambers encapsulated with pulverized drug for bacteria-based microrobots

“…I I I I I I I I I I I ISRC 15 OkV 13 5mm x1 20k 400um During the x-ray lithography process, the exposed dose to encapsulated Lapatinib is 0.002 kJ/cm 3 . Varshney et al have reported that cyclophosphamide (CPH) and doxorubicin hydrochloride (DOXO) do not undergo degradation or discoloration after being irradiated by gamma radiation of 5 kGy [22] which is equivalent to 0.007 kJ/cm 3 . Therefore, it can be assumed that the encapsulated Lapatinib will have insignificant physicochemical changes, and that the fabricated micro chamber can be used for bacteria-based microrobots.…”

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

“…It is better to carry out product analysis if a more accurate degradation value is required. Thus, in the study by Varshney and Dodke (2004), product analysis, showed that cyclophosphamide degraded by 1.7% at 30 kGy. Other extensive studies involving product analysis, such as hplc, nmr, hplc-ms, epr, tlc, etc., have been carried out by Marciniec and co-workers, largely using electron beam irradiation up to doses as high as 800 kGy.…”