Effects of irradiation with low-energy helium, krypton, and xenon ions on the structural and mechanical properties of the TiNbN coatings on 12Cr18Ni10Ti steel substrates are studied. The samples with TiNbN coatings on stainless steel were prepared by magnetron sputtering technique using two magnetrons with sputtering targets of titanium and niobium. Irradiations with 4 He 2+ , 84 Kr 14+ , and 132 Xe 18+ ions were performed in the low-energy channel of the accelerator DC-60 with an energy of 20 keV/charge up to the fluence 1 × 10 16 cm −2 , 5 × 10 16 cm −2 , and 1 × 10 17 cm −2. Structure, element composition, thickness, surface morphology, hardness, and corrosion resistance of the coatings were studied by X-ray diffractometry, Rutherford backscattering on nitrogen, scanning electron microscopy, atomic force microscopy, nanohardness and corrosion rate measurements. It was found that the TiNbN coating significantly exceeds Cr18Ni10Ti stainless steel in the entire range of studied properties, such as strength, corrosion resistance, and tendency towards blistering. In spite of structural and physical-mechanical properties degradation under ion irradiation, the TiNbN coating demonstrates good mechanical properties which are better than those of unirradiated steel Cr18Ni10Ti.