One of most import noise sources in a jet powered aircraft is turbulent boundary layer (TBL) induced structural vibration. In this chapter, the general model for the prediction of TBL-induced plate vibration and noise is described in detail. Then numerical examples for a typical plate are illustrated. Comparisons of plate vibration and radiated noise between numerical results and wind tunnel test are presented. The effects of structural parameters on modal-averaged radiation efficiency and therefore the radiated noise are discussed. The result indicates that an increment of flow velocity will increase the acoustic radiation efficiency below the hydrodynamic coincidence frequency range. The main reason for this phenomenon is that a higher convection velocity will coincide with lower order modes which have higher radiation efficiencies.