Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

Magaña, Héctor; Palomino, Kenia; Cornejo-Bravo, José Manuel; Alvarez‐Lorenzo, Carmen; Concheiro, Angel; Bucio, Emilio

doi:10.1016/j.radphyschem.2014.10.011

Cited by 19 publications

(8 citation statements)

References 27 publications

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“…A previous report on grafting acrylamide film/gel on PTFE surfaces modified with ϒ‐ray radiation showed that no grafting was achieved with momoner concentations less than 10% and reaction temperatures below 57 °C. [ 66 ] The minimum reaction time required to achieve a significant grafting yield for the acrylamide film/gel on the ϒ‐irradiated PTFE surface was approximately 2 h. In the case of PIII‐treated PTFE, however, we achieved hydrogel formation with only 1% monomer concentration at 80 °C or 40% monomer concentration at room temprature with reaction times of only 50 min suggesting that the PIII‐treated surface was much more reactive.…”

Section: Resultsmentioning

confidence: 95%

Hydrogel−Solid Hybrid Materials for Biomedical Applications Enabled by Surface‐Embedded Radicals

Walia

Akhavan

Kosobrodova

et al. 2020

Adv Funct Materials

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Combinations of hydrogels and solids provide high level functionality for devices such as tissue engineering scaffolds and soft machines. However, the weak bonding between hydrogels and solids hampers functionality. Here, a versatile strategy to develop mechanically robust solid−hydrogel hybrid materials using surface embedded radicals generated through plasma immersion ion implantation (PIII) of polymeric surfaces is reported. Evidence is provided that the reactive radicals play a dual role: inducing surface‐initiated, spontaneous polymerization of hydrogels; and binding the hydrogels to the surfaces. Acrylamide and silk hydrogels are formed and covalently attached through spontaneous reactions with the radicals on PIII activated polymer surfaces without cross‐linking agents or initiators. The hydrogel amount increases with incubation time, monomer concentration, and temperature. Stability tests indicate that 95% of the hydrogel is retained even after 4 months in PBS solution. T‐peel tests show that failure occurs at the tape−hydrogel interface and the hydrogel‐PIII‐treated PTFE interfacial adhesion strength is over 300 N m−1. Cell assays show no adhesion to the as‐synthesized hydrogels; however, hydrogels synthesized with fibronectin enable cell adhesion and spreading. These results show that polymers functionalized with surface‐embedded radicals provide excellent solid platforms for the generation of robust solid−hydrogel hybrid structures for biomedical applications.

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Section: Resultsmentioning

confidence: 95%

Hydrogel−Solid Hybrid Materials for Biomedical Applications Enabled by Surface‐Embedded Radicals

Walia

Akhavan

Kosobrodova

et al. 2020

Adv Funct Materials

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“…Nevertheless, even for the SR-g-(NVCL-co-4VP) film with the highest grafting percentage tested, the amount of diclofenac loaded was above 1 mg/g, which may be suitable for obtaining therapeutic effects. [ 22,31,39 ]…”

Section: Resultsmentioning

confidence: 99%

One-step grafting of temperature-and pH-sensitive (N-vinylcaprolactam-co-4-vinylpyridine) onto silicone rubber for drug delivery

Pino‐Ramos

Alvarez‐Lorenzo

Bucio

2016

Designed Monomers and Polymers

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A one-step method was implemented to graft N-vinylcaprolactam (NVCL) and 4-vinylpyridine (4VP) onto silicone rubber (SR) films using gamma radiation in order to endow the silicone surface with temperature- and pH-responsiveness, and give it the ability to host and release diclofenac in a controlled manner and thus prevent bacterial adhesion. The effects of radiation conditions (e.g., dose and monomers concentration) on the grafting percentage were evaluated, and the modified films were characterized by means of FTIR-ATR, Raman spectroscopy, calorimetry techniques (DSC and TGA) and contact angle measurements. The films responsiveness to stimuli was evaluated by recording the swelling degree of pristine and modified SR in buffer solutions (critical pH point) and as a function of changes in temperature (Upper Critical Solution Temperature, UCST). The graft copolymers of SR-g-(NVCL-co-4VP) showed good cytocompatibility against fibroblast cells for prolonged times, could host diclofenac and release it in a sustained manner for up to 24 h, and exhibited bacteriostatic activity when challenged against Escherichia coli.

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“…The classification is either neutral or ionic copolymer. Examples of neutral monomers are perfluoroacrylate and acrylamide (Magaña et al 2015). Ionic copolymer may be divided into anionic, cationic and bipolar.…”

Section: Introductionmentioning

confidence: 99%

Modification of PTFE Flat Sheet Film via Radiation Induced Grafting Polymerization with Acrylic Acid

Ghani¹,

Hamzah²,

Mohamed³

2020

JSM

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Polytetrafluoroethylene (PTFE) flat sheet film was modified with acrylic acid (AAC) by radiation induced grafting polymerization (RIGP) method using electron beam. The adsorbed doses were varied from 10 to 50 kGy, time of grafting from 1 to 3 h and monomer concentration and temperature were kept constant at 30 wt. % and 40ºC. The degree of grafting (D g) and equilibrium degree of swelling (EDS) of the grafted films were then determined. The films were further characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), X-ray diffraction (XRD), and optical water contact angle. D g within the range of 17% to 210% were obtained for doses from 10 to 50 kGy within time of grafting from 1 to 3 h. The grafted film (PTFE-g-AAC) showed increased hydrophilicity leading to an increase in EDS. The successful grafting process was confirmed by FTIR results that showed characteristics peaks for carbonyl and hydroxyl group and a decrease in crystallinity for the PTFE-g-AACfilm. SEM images showed that PTFE-g-AAC films had less fibrillar compared to PTFE film and was consistent with the decrease in roughness for the PTFE-g-AAC film. This study indicated that modifying PTFE film by grafting AAC could significantly improve the hydrophilicity of PTFE film. The PTFE-g-AAC films has potential as a heavy metal adsorbent as it can remove at least 75% of Fe ion and 50 % of Pb ion from competitive media.

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Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

Cited by 19 publications

References 27 publications

Hydrogel−Solid Hybrid Materials for Biomedical Applications Enabled by Surface‐Embedded Radicals

Hydrogel−Solid Hybrid Materials for Biomedical Applications Enabled by Surface‐Embedded Radicals

One-step grafting of temperature-and pH-sensitive (N-vinylcaprolactam-co-4-vinylpyridine) onto silicone rubber for drug delivery

Modification of PTFE Flat Sheet Film via Radiation Induced Grafting Polymerization with Acrylic Acid

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